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Indication & Dosage |
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| Oral |
| TREATMENT OF DIABETIC NEUROPATHIC OEDEMA |
| Adult:
As hydrochloride: 30-60 mg tid. |
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| Intravenous |
| REVERSAL OF SPINAL OR EPIDURAL ANAESTHESIA-INDUCED HYPOTENSION |
| Adult:
3-6 mg or up to 9 mg in a 3 mg/mL soln given as slow Inj repeated every 3-4 min, as needed. |
| Max Dosage: 30mg |
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| Administration |
May be taken with or without food. |
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| Precautions |
Ischaemic heart disease, hyperthyroidism, diabetes mellitus, hypertension, angle-closure glaucoma, renal impairment; prostatic enlargement; pregnancy, elderly. |
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Potentially Life-threatening
Adverse Drug Reactions |
Anxiety, tachycardia, tremor, dry mouth, hypertension, cardiac arrhythmias, impaired circulation to the extremities, nervousness, insomnia, palpitations. Difficulty in micturition in patients with prostatic enlargement. Nasal drops: Local irritation, rebound nasal congestion and drug-induced rhinitis on prolonged use. |
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| Adverse Drug Reactions |
Delusions, hallucinations. Seen with hypersensitivity and overdosage. Acute CNS and CVS stimulation presenting as vomiting, fever, hypertension, psychosis. Cardiac arrhythmias. |
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| Interactions |
Severe HTN when combined with MAOIs or withi 2 wk of discontinuance of MAOI treatment. Increased risk of arrhythmias with cardiac glycosides, quinidine or tricyclic antidepressants. Increased vasoconstriction or pressor effects with ergot alkaloids or oxytocin. Reduces antihypertensive effect of bethanidine and guanethidine. May increase clearance of dexamethasone. Increased incidence of adverse effects when used with theophylline. |
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