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Indication & Dosage |
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| Intravenous |
| AS AN ADJUNCT TO GENERAL ANAESTHESIA IN PATIENTS WITH SPONTANEOUS RESPIRATION |
| Adult:
Initially, 50-200 mcg followed by supplements of 50 mcg. |
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| Intravenous |
| AS AN ADJUNCT TO GENERAL ANAESTHESIA IN PATIENTS WITH SPONTANEOUS RESPIRATION |
| Child:
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| Intravenous |
| AS AN ADJUNCT TO GENERAL ANAESTHESIA IN PATIENTS WITH SPONTANEOUS RESPIRATION |
| Adult:
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| Intravenous |
| AS AN ADJUNCT TO GENERAL ANAESTHESIA IN PATIENTS WITH ASSISTED VENTILATION |
| Adult:
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| Max Dosage: 50 mcg/kg. |
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| Transdermal |
| TREATMENT OF INTRACTABLE CHRONIC CANCER PAIN IN PATIENTS RECEIVING STRONG OPIOID ANALGESIC |
| Adult:
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| Precautions |
Myasthaenia graivs; muscle rigidity may worsen resp depression. Head injury; renal or hepatic impairment; elderly, debilitated patients, neonates. Use with caution in patients with hypothyroidism, prostatic hyperplasia, inflammatory bowel disorders. |
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Potentially Life-threatening
Adverse Drug Reactions |
Nausea, vomiting; bradycardia, transient hypotension, peripheral vasodilation; drowsiness, sedation; increased intracranial pressure. Transdermal: Rash, erythema and itching. |
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| Adverse Drug Reactions |
Respiratory depression, trunk rigidity, laryngospasm, bronchoconstriction. |
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| Interactions |
Depressant effects may be enhanced by other CNS depressants such as alcohol, anaesthetics, anxiolytics, hypnotics, tricyclic antidepressants, and antipsychotics. |
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