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Indication & Dosage |
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Oral |
TREATMENT OF DEPRESSION |
Adult:
20 mg daily |
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Oral |
MANAGEMENT OF BULIMIA NERVOSA |
Adult:
60 mg daily. |
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Oral |
TREATMENT OF DEPRESSION |
Child:
8-18 yr: 10-20 mg daily; initiate at 10 mg daily for lower-wt children, may increase to 20 mg/day after 1 wk if necessary.
Elderly: Initially, 10 mg daily, may increase by 10-20 mg every few wk as tolerated. |
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Oral |
TREATMENT OF PREMENSTRUAL DYSPHORIC DISORDER |
Adult:
20 mg daily continuously. Alternatively, 20 mg daily, to be started 14 days before onset of menstruation and continue until 1st day of menses. May repeat with each cycle, if needed. |
Max Dosage: 80 mg daily. |
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Oral |
TREATMENT OF PANIC DISORDER |
Adult:
Initial dose: 10 mg daily, may increase to 20 mg daily after a wk. May increase to 60 mg daily after a few wk, if needed. |
Max Dosage: 80 mg daily. |
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Oral |
OBSESSIVE COMPULSIVE DISORDER |
Adult:
Initially, 20 mg daily increased up to 60 mg daily after several wk if unresponsive. Max: 80 mg daily. |
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Oral |
OBSESSIVE COMPULSIVE DISORDER |
Adult:
Initially, 20 mg daily increased up to 60 mg daily after several wk if unresponsive. Max: 80 mg daily. |
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Administration |
May be taken with or without food. |
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Precautions |
Unstable epilepsy, liver and renal impairment, cardiac disease, diabetes, electroconvulsive therapy, bleeding disorders, closed-angle glaucome; pregnancy. May impair performace of skilled tasks; withdraw gradually. Close monitoring of clinical worsening and behavioural changes during the 1st few mths of treatment or when there are dose changes. |
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Potentially Life-threatening
Adverse Drug Reactions |
Nervousness, insomnia, anxiety, headache, tremor, drowsiness, dry mouth, nausea, vomiting, sweating, diarrhoea. Seizures, mania, hypomania or mixed manic states reported. Hyponatraemia; elevation of hepatic enzymes. |
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Adverse Drug Reactions |
Rarely, systemic events possibly related to vasculitis have been reported in patients with rash but may be serious involving lungs, kidney and liver. |
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Interactions |
May cause transient shift in plasma conc of tightly protein bound drugs eg, warfarin and digoxin, resulting in adverse effects. T½ of diazepam is prolonged. |
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