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Indication & Dosage
 
 
Oral
TREATMENT OF DEPRESSION
Adult: 20 mg daily
 
Oral
MANAGEMENT OF BULIMIA NERVOSA
Adult: 60 mg daily.
 
Oral
TREATMENT OF DEPRESSION
Child: 8-18 yr: 10-20 mg daily; initiate at 10 mg daily for lower-wt children, may increase to 20 mg/day after 1 wk if necessary. Elderly: Initially, 10 mg daily, may increase by 10-20 mg every few wk as tolerated.
 
Oral
TREATMENT OF PREMENSTRUAL DYSPHORIC DISORDER
Adult: 20 mg daily continuously. Alternatively, 20 mg daily, to be started 14 days before onset of menstruation and continue until 1st day of menses. May repeat with each cycle, if needed.
Max Dosage:  80 mg daily.
 
Oral
TREATMENT OF PANIC DISORDER
Adult: Initial dose: 10 mg daily, may increase to 20 mg daily after a wk. May increase to 60 mg daily after a few wk, if needed.
Max Dosage:  80 mg daily.
 
Oral
OBSESSIVE COMPULSIVE DISORDER
Adult: Initially, 20 mg daily increased up to 60 mg daily after several wk if unresponsive. Max: 80 mg daily.
 
Oral
OBSESSIVE COMPULSIVE DISORDER
Adult: Initially, 20 mg daily increased up to 60 mg daily after several wk if unresponsive. Max: 80 mg daily.
   
Administration May be taken with or without food.
   
Precautions Unstable epilepsy, liver and renal impairment, cardiac disease, diabetes, electroconvulsive therapy, bleeding disorders, closed-angle glaucome; pregnancy. May impair performace of skilled tasks; withdraw gradually. Close monitoring of clinical worsening and behavioural changes during the 1st few mths of treatment or when there are dose changes.
   
Potentially Life-threatening 
Adverse Drug Reactions

Nervousness, insomnia, anxiety, headache, tremor, drowsiness, dry mouth, nausea, vomiting, sweating, diarrhoea. Seizures, mania, hypomania or mixed manic states reported. Hyponatraemia; elevation of hepatic enzymes.

   
Adverse Drug Reactions Rarely, systemic events possibly related to vasculitis have been reported in patients with rash but may be serious involving lungs, kidney and liver.
   
Interactions May cause transient shift in plasma conc of tightly protein bound drugs eg, warfarin and digoxin, resulting in adverse effects. T½ of diazepam is prolonged.
   
   
 

 

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