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ANATENSOL DECANOATE  FLUDECAN  PROLINATE 
 



Indication & Dosage
 
 
Oral
TREATMENT OF PSYCHOSES
Adult: Initially, 2.5-10 mg daily in 2-3 divided doses, increased according to reponse. Maintenance: 1-5 mg daily.
Max Dosage:  Adult: 20 mg/day. Elderly: 10 mg/day.
 
Oral
MANIA
Adult: Initially, 2.5-10 mg daily in 2-3 divided doses, increased according to reponse. Maintenance: 1-5 mg daily.
Max Dosage:  Adult: 20 mg/day. Elderly: 10 mg/day.
 
Oral
SCHIZOPHRENIA
Adult: Initially, 2.5-10 mg daily in 2-3 divided doses, increased according to reponse. Maintenance: 1-5 mg daily.
Max Dosage:  Adult: 20 mg/day. Elderly: 10 mg/day.
 
Oral
SHORT-TERM ADJUNCTIVE MANAGEMENT OF SEVERE ANXIETY OR BEHAVIORAL DISTURBANCES
Adult: 1 mg bid increased to 2 mg bid if necessary.
 
Intramuscular
TREATMENT OF PSYCHOSES
Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg. The enantate ester can be given in similar doses at intervals of 1-3 wk.
Max Dosage:  6.25 mg adjusted according to response.
 
Intramuscular
MANIA
Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg. The enantate ester can be given in similar doses at intervals of 1-3 wk.
Max Dosage:  6.25 mg adjusted according to response.
 
Intramuscular
SCHIZOPHRENIA
Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg. The enantate ester can be given in similar doses at intervals of 1-3 wk.
Max Dosage:  6.25 mg adjusted according to response.
   
Administration May be taken with or without food.
   
Precautions Presence of convulsive disorders; hepatic, renal, cerebrovascular, resp and CV diseases; elderly or debilitated patients. May elevate prolactin levels which may persist after chronic admin. May exacerbate depression. Closed-angle glaucoma. History of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations in patients receiving long term therapy. Avoid direct sunlight exposure.
   
Potentially Life-threatening 
Adverse Drug Reactions
Tardive dyskinesia, sedation, mental confusion; hypotension; hyperprolactinaemia leading to galactorrhoea and amenorrhoea in women; loss of libido, impotence and sterility in males. Allergic reactions, cholestatic jaundice, corneal and lens deposits, skin pigmentation.
   
Adverse Drug Reactions Agranulocytosis; neuroleptic malignant syndrome.
   
Interactions

Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.

Reduces antihypertensive effects of guanethidine, methyldopa and clonidine. Lithium toxicity. Reduced bioavailability with antacids. Increased risk of arrhythmia when used with drugs that prolong QT interval. May cause electrolyte disturbance when used with diuretics.

   
   
 

 

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