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Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
| Adult:
As maleate: Initially, 50-100 mg daily, may increase gradually up to 300 mg daily, if necessary. Doses >100 mg should be given in divided doses. |
| Max Dosage: 300 mg |
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| Oral |
| MANAGEMENT OF OBSESSIVE-COMPULSIVE DISORDERS |
| Adult:
50 mg once daily; may increase by 50 mg every 4-7 days. Daily doses >100 mg should be given in 2 divided doses. As modified-release preparation: Initial: 100 mg once daily. Max: 300 mg daily. |
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| Oral |
| MANAGEMENT OF OBSESSIVE-COMPULSIVE DISORDERS |
| Child:
≥8 yr: 25 mg once daily, may increase by 25 mg every 4-7 days. Doses >50 mg should be given in 2 divided doses. Reassess if no improvement after 10 wk of treatment. Max: 200 mg daily. |
| Max Dosage: Adult: 300 mg daily. Child:200 mg daily |
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| Oral |
| SOCIAL ANXIETY DISORDER |
| Adult:
As modified-release preparation: Initial: 100 mg once daily. Max: 300 mg daily. |
| Max Dosage: 300 mg |
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| Administration |
May be taken with or without food. |
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| Precautions |
History of mania or seizures; liver dysfunction; presence of depressive symptoms; smokers. Treatment with MAOI should only be started at least 2 wk after stopping fluvoxamine treatment. Increased risk of suicidal ideation and behaviour when used in children, adolescents and young adults <24 yr. Pregnancy, elderly; operating hazardous machinery; withdraw gradually. Monitor prothrombin time in patients who are taking oral anticoagulants concurrently. |
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| Adverse Drug Reactions |
Headache, asthenia, tremor, palpitations, nausea, diarrhoea, constipation, anorexia, vomiting, flatulence, somnolence, insomnia, dry mouth, nervousness, dizziness, tremor, anxiety, agitation, decreased libido, depression, CNS stimulation, dyspnoea, yawn, sweating, abnormal ejaculation, urinary frequency, anorgasmia, urinary retention. |
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| Interactions |
Co-admin with fluvoxamine may increase carbamazepine toxicity and serum levels of theophylline. Lithium enhances the serotonergic effects of fluvoxamine. Anticoagulants may require dosage adjustments. Diltiazem with fluvoxamine may lead to bradycardia. Avoid alcohol. |
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