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Indication & Dosage |
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| Oral |
| MALIGNANT NEOPLASMS OF THE PROSTATE |
| Adult:
360-480 mg tid. Maintenance: 120-240 mg tid; may gradually reduce to 240 mg daily. |
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| Intravenous |
| MALIGNANT NEOPLASMS OF THE PROSTATE |
| Adult:
Initially, 600-1200 mg daily by slow IV Inj for 5-10 days followed by 300 mg daily for 10-20 days. Maintenance: 300-600 mg, reduce slowly over few mth from dosing 4 times/wk to once wkly. |
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| Precautions |
Cardiovascular disease, hepatic impairment. Slow infusion is not recommended. |
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| Adverse Drug Reactions |
Nausea, fluid retention, arterial and venous thrombosis, impotence, gynecomastia, withdrawal bleeding, hypercalcaemia, bone pain. |
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