Adult:
As Phenytoin Na Equivalents (PSE): Initially, 15 mg/kg infused IV at a rate of 100-150 mg/min. Maintenance: 4-5 mg PSE/kg/day by IM inj or IV infusion at a rate of 50-100 mg PSE/min.
Parenteral
TREATMENT OF TONIC-CLONIC STATUS EPILEPTICUS
Child:
≥5 yr: As Phenytoin sodium equivalents (PSE): Loading dose: 15 mg/kg, given via IV infusion at a rate of 2-3 mg/kg/minute. Maintenance: Initially, 4-5 mg/kg/day by IM inj or IV infusion at a rate of 1-2 mg/kg/minute; subsequent doses depend on patient's response and trough-plasma phenytoin levels.
Parenteral
TREATMENT OF SEIZURES OTHER THAN STATUS EPILEPTICUS
Adult:
As Phenytoin sodium equivalents (PSE): Loading dose: 10-15 mg/kg, given via IM inj or IV infusion at a rate of 50-100 mg/minute. Maintenance: Initially, 4-5 mg/kg/day by IM inj or IV infusion at a rate of 50-100 mg/minute; subsequent doses depend on patient's response and trough-plasma phenytoin levels.
Parenteral
TREATMENT OF SEIZURES OTHER THAN STATUS EPILEPTICUS
Child:
≥5 yr: As Phenytoin sodium equivalents (PSE): Loading dose: 10-15 mg/kg, given via IM inj or IV infusion at a rate of 1-2 mg/kg/minute. Maintenance: Initially, 4-5 mg/kg/day by IM inj or IV infusion at a rate of 1-2 mg/kg/minute; subsequent doses depend on patient's response and trough-plasma phenytoin levels.
Precautions
Hepatic or renal impairment; hypoalbuminaemia; elderly; patients needing phosphate restriction; resuscitation facilities must be available; monitor ECG, BP and resp function for the duration of infusion; observe patient for at least 30 min after the end of infusion.
Potentially Life-threatening
Adverse Drug Reactions
Burning, itching and paraesthesia in the groin area following IV administration; asystole, ventricular fibrillation, hypotension, bradycardia, heart block.
Adverse Drug Reactions
Severe CV reactions.
Interactions
Other antiepileptics; drugs competing for protein-binding sites; halothane; aspirin, phenylbutazone, azapropazone, fenyramidol; dextropropoxyphene; some antibacterials, anticoagulants, antidepressants, antidiabetics, antifungals, antigout drugs and antihistamines. Enhanced hypotensive properties of dopamine and cardiac depressant properties of lidocain
