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Indication & Dosage |
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| Oral |
| ACUTE BACTERIAL EXACERBATION OF CHRONIC BRONCHITIS |
| Adult:
320 mg once daily for 5 days. |
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| Oral |
| COMMUNITY-ACQUIRED PNEUMONIA (MILD TO MODERATE SEVERITY) |
| Adult:
320 mg once daily for 7 days. |
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| Administration |
May be taken with or without food. |
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| Precautions |
History of prolongation of QT interval, uncorrected electrolyte disorders, CNS diseases such as epilepsy. Maintain adequate hydration. Increased risk of rash when treatment duration is prolonged. Children <18 yr. Pregnancy, lactation. |
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| Adverse Drug Reactions |
Diarrhoea, nausea, vomiting; headache, dizziness; rash, urticaria. May cause elevation of liver enzymes. |
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| Interactions |
Lower bioavailability if coadministered with multivalent cation preparations e.g. aluminum, magnesium, or iron salts. May potentiate QT prolongation when used with drugs that affect the QT interval e.g. cisapride, erythromycin, antipsychotics and TCAs. May increase prothrombin time when used with warfarin or its derivatives. Increased plasma levels when used with probenecid. |
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