Indication & Dosage |
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| Subcutaneous |
| PROPHYLAXIS OF VENOUS THROMBOEMBOLISM DURING SURGICAL PROCEDURES |
| Adult:
Moderate-risk patients: 2850 units daily for 7 days or until the patient is ambulant; give the 1st dose 2-4 hr before surgery. High-risk patients: 38 units/kg 12 hr before surgery, 12 hr post-operatively and then daily until 3 days after surgery; increase dose by 50% to 57 units/kg daily. Total duration of treatment: At least 10 days. |
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| Precautions |
Patients with recent or anticipated neuraxial anaesthesia; history of heparin-induced thrombocytopenia, congenital or drug-induced thrombocytopenia or platelet defects; patients at increased risk of bleeding; severe hepatic or renal disease. Monitor for signs of bleeding; hyperkalaemia. Pregnancy. |
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| Adverse Drug Reactions |
Hypoaldosteronism; bleeding, thrombocytopenia; rash; haematoma and pain at inj site; allergic reactions; osteopaenic effects; increased ALT/AST. |
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| Interactions |
Increased risk of bleeding with thrombolytic agents, oral anticoagulants and antiplatelet drugs. |
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