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Indication & Dosage
 
 
Oral
CHEMOTHERAPY-RELATED EMESIS
Adult: 1-2 mg within 1 hr before the start of chemotherapy, then 2 mg daily in 1-2 divided doses during treatment.
 
Oral
CHEMOTHERAPY-RELATED EMESIS
Child: 1 mth–12 yr: 20 mcg/kg (max: 1 mg) within 1 hr before chemotherapy, then 20 mcg/kg (max: 1 mg) bid for up to 5 days during treatment.
 
Oral
PROPHYLAXIS OF NAUSEA AND VOMITING ASSOCIATED WITH RADIATION THERAPY
Adult: 2 mg daily within 1 hr of irradiation
 
Intravenous
CHEMOTHERAPY-RELATED EMESIS
Adult: 3 mg diluted to 20-50 ml with a suitable infusion solution, given over 5 minutes before the start of chemotherapy. Alternatively, 3 mg given in 15 ml of infusion solution given as bolus over at least 30 sec. May repeat dose up to twice within 24 hr. Doses should be given at least 10 minutes apart. Max: 9 mg daily.
Max Dosage:   9 mg daily.
 
Intravenous
CHEMOTHERAPY-RELATED EMESIS
Child: 40 mcg/kg (max 3 mg), in 10-30 ml of infusion fluid given over 5 minutes, may repeat once within 24 hr, at least 10 minutes apart from the 1st dose. 1st dose should be given within 1 hr of the start of chemotherapy
 
Intravenous
PROPHYLAXIS AND TREATMENT OF POSTOPERATIVE NAUSEA AND VOMITING
Adult: 1 mg diluted to 5 ml, injected over 30 sec. To be completed before induction of anaesthesia. May be given up to bid for the treatment of postoperative nausea and vomiting.
   
Administration May be taken with or without food. (Take up to 1 hr before chemotherapy.)
   
Precautions Patients with signs of subacute intestinal obstruction or ileus; moderate to severe hepatic impairment. Pregnancy and lactation.
   
Adverse Drug Reactions Headache; sensation of flushing; constipation; hypersensitivity reactions; chest pain; CV disturbances; dizziness; transient visual disturbances. Rarely, liver disorders; development of seizures; extrapyramidal reactions.
   
Interactions

Potent cytochrome P450 enzyme inducers or inhibitors.

   
   
 

 

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