 |
Indication & Dosage |
| |
| |
| Intravenous |
| MANAGEMENT OF UNSTABLE ANGINA |
| Adult:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Intravenous |
| MANAGEMENT OF UNSTABLE ANGINA |
| Child:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Intravenous |
| TREATMENT OF VENOUS THROMBOEMBOLISM |
| Adult:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Intravenous |
| TREATMENT OF VENOUS THROMBOEMBOLISM |
| Child:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Subcutaneous |
| TREATMENT OF VENOUS THROMBOEMBOLISM |
| Adult:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Subcutaneous |
| TREATMENT OF VENOUS THROMBOEMBOLISM |
| Child:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Subcutaneous |
| PROPHYLAXIS OF POSTOPERATIVE VENOUS THROMBOEMBOLISM INCLUDING DURING PREGNANCY WITH A HISTORY OF DEEP-VEIN THROMBOSIS OR PULMONARY EMBOLISM |
| Adult:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Subcutaneous |
| PREVENTION OF MURAL THROMBOSIS |
| Adult:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
| |
| Parenteral |
| PREVENTION OF RE-OCCLUSION OF THE CORONARY ARTERIES FOLLOWING THROMBOLYTIC THERAPY IN MYOCARDIAL INFARCTION |
| Adult:
5000 u (10,000 u in severe pulmonary embolism) IV loading dose followed by 1000-2000 u/hr continuous infusion. Alternatively, intermittent inj of 5000-10,000 u every 4-6 hr. |
|
| |
|
| Precautions |
Monitor platelet counts. Discontinue treatment if thrombocytopenia occurs. Hypersensitivity, elderly, pregnancy. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Slight fever, headache, chills, nausea, vomiting, constipation, epistaxis, bruising, slight haematuria, skin necrosis (SC inj), osteoporosis, alopecia. Hypersensitivity reactions include urticaria, conjunctivitis, rhinitis, asthma, angioedema and anaphylactic shock. Priapism. |
| |
|
| Adverse Drug Reactions |
Heparin-induced thrombocytopenia with or without thrombosis; bleeding. |
| |
|
| Interactions |
Inhibited by zinc. Antiplatelet drugs e.g. aspirin and dipyridamole may precipitate bleeding. |
| |
|
|
|
