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Indication & Dosage
 
 
Oral
SHORT-TERM MANAGEMENT OF ANXIETY DISORDERS
Adult: 50-100 mg qid.
 
Oral
PRURITUS IN ACUTE AND CHRONIC URTICARIA AND DERMATOSIS
Adult: Initially, 25 mg at night increased if required up to 25 mg 3-4 times daily.
 
Oral
PRURITUS IN ACUTE AND CHRONIC URTICARIA AND DERMATOSIS
Child: 6 mth-6 yr: 5-15 mg daily, increased to 50 mg/day in divided doses; >6 yr: Initially, 15-25 mg/day, increased up to 50-100 mg/day.
 
Oral
ADJUNCT TO PRE- OR POSTOPERATIVE SEDATION
Adult: 50-100 mg.
 
Oral
ADJUNCT TO PRE- OR POSTOPERATIVE SEDATION
Child: 600 mcg/kg.
 
Intramuscular
PROMPT CONTROL OF ANXIETY OR AGITATION
Adult: Initially, 50-100 mg, may repeat every 4-6 hr if necessary.
   
Administration May be taken with or without food.
   
Precautions Renal and hepatic impairment; narrow-angle glaucoma; epilepsy; prostatic hypertrophy; bladder neck obstruction; asthma; chronic obstructive pulmonary disease; tasks requiring mental alertness eg, drving or operating machinery.
   
Adverse Drug Reactions CNS depression, paradoxical CNS stimulation (childn), dry mouth, thickened resp secretions, constipation, blurring of vision, tachycardia, GI disturbances, headache, hypotension, tinnitus.
   
Interactions

Potentiates CNS depression by, barbiturates, hypnotics, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, and tricyclic antidepressants potentiate antimuscarinic effects.

Masks ototoxicity of aminoglycoside antibiotics. Increased CNS depression with alcohol or CNS depressants.

   
   
 

 

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