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Indication & Dosage |
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| Oral |
| HIV INFECTION |
| Adult:
800 mg every 8 hr. Dose reduction may be required when used with delavirdine, itraconazole, ketoconazole and rifabutin. |
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| Oral |
| HIV INFECTION |
| Child:
>4 yr: 500 mg/m2 every 8 hr without exceeding adult dose |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Best taken w/ plain water on an empty stomach 1 hr before or 2 hr after meals. May also be taken w/ other liqds eg skim milk, juice, coffee, tea or a light meal. Ensure adequate hydration.) |
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| Precautions |
Increased risk of urolithiasis/nephrolithiasis. Ensure adequate hydration. Hyperbilirubinaemia may be exacerbated. Diabetes; haemophilia. Monitor for signs of lipodystrophy. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Flank pain, abdominal pain, nephrolithiasis, malaise, nausea, vomiting, diarrhoea, elevated liver enzymes, hyperbilirubinaemia, raised creatinine phosphokinase and blood lipids, back pain, lipodystrophy, alopecia, acid regurgitation, dyspepsia, dry mouth, dysuria, dry skin, hyperpigmentation, headache, dizziness, somnolence, cough, dyspnoea. |
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| Adverse Drug Reactions |
Acute haemolytic anemia; acute hepatitis. |
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| Interactions |
Reduced absorption with antacids. Increased concentrations with ketoconazole, delavirdine, nelfinavir and ritonavir. Reduced efficacy with nevirapine, efavirenz or rifampicin. Increased risk of myopathy with statins. Increased concentrations of phosphodiesterase-5 inhibitors. |
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