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FASTUM GEL  KETOFEN  KETOPATCH  OSTOFEN  RHOFENID  RHOFENID  RHOFENID  RHOFENID GEL  VOFANE 
 



Indication & Dosage
 
 
Oral
RHEUMATIC DISORDERS
Adult: 100-200 mg/day in 2-4 divided doses. As modified-release formulation: Administer dose once daily. Max dose: 200 mg daily (combined oral and rectal forms).
Elderly: >75 yr: Reduce initial dose.
 
Oral
OTHER PAINFUL CONDITIONS INCLUDING DYSMENORRHOEA
Adult: 25-50 mg every 6-8 hr. Max: 200 mg daily (combined oral and rectal forms). Elderly: >75 yr: Reduce initial dose.
Max Dosage:  200 mg daily (combined oral and rectal forms).
 
Intramuscular
ACUTE EXACERBATIONS OF MUSCULOSKELETAL, JOINT, PERIARTICULAR AND SOFT-TISSUE DISORDERS
Adult: 50-100 mg by deep inj into the gluteal muscle every 4 hr. Max: 200 mg in 24 hr for up to 3 days.
Max Dosage:   200 mg in 24 hr for up to 3 days.
 
Intramuscular
PAIN FOLLOWING ORTHOPAEDIC SURGERY
Adult: 50-100 mg by deep inj into the gluteal muscle every 4 hr. Max: 200 mg in 24 hr for up to 3 days.
 
Rectal
RHEUMATIC DISORDERS
Adult: 100 mg at night or bid. Max: 200 mg daily (combined oral and rectal forms).
 
Topical/Cutaneous
LOCAL PAIN
Adult: Apply 2.5% gel bid-tid for up to 10 days.
   
Administration Should be taken with food. (Preferably taken w/ or after meals.)
   
Precautions Pregnancy, lactation. Renal or hepatic impairment. Elderly. Heart failure.
   
Potentially Life-threatening 
Adverse Drug Reactions
Acute interstitial nephritis, reversible decline in renal function; GI symptoms e.g. discomfort, nausea, diarrhoea; pain and tissue damage at inj site (IM).
   
Adverse Drug Reactions Rarely, idiosyncrasy, anaphylaxis; very rarely GI haemorrhage.
   
Interactions Risk of nephrotoxicity increased with ACE inhibitors, ciclosporin, tacrolimus or diuretics. Increased risk of hyperkalaemia with ACE inhibitors and potassium-sparing diuretics. Reduces effects of antihypertensives (e.g. ACE inhibitors, β-blockers). Increased risk of convulsions with quinolones. Increased risk of adverse effects with aspirin. Increased risk of GI bleeding and ulceration with corticosteroids, SSRIs, clopidogrel and ticlopidine. Increased risk of haematotoxicity with zidovudine. May alter the efficacy of mifepristone. Increased plasma levels with probenecid.
   
   
 

 

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