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Indication & Dosage |
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| Oral |
| SHORT-TERM MANAGEMENT OF MODERATE TO SEVERE POSTOPERATIVE PAIN |
| Adult:
As trometamol: 10 mg every 4-6 hr. Max dose: 40 mg/day. Max duration: 7 days.
Elderly: 10 mg every 6-8 hr. Max dose: 40 mg/day. Max duration: 7 days. |
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| Parenteral |
| SHORT-TERM MANAGEMENT OF MODERATE TO SEVERE POSTOPERATIVE PAIN |
| Adult:
As trometamol: 10 mg IM/IV followed by 10-30 mg every 4-6 hr if necessary. Max: 90 mg/day (60 mg/day in patients weighing <50 kg).
Elderly: Max: 60 mg/day. |
| Max Dosage: Max dose: 60 mg/day. |
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| Ophthalmic |
| RELIEF OF OCULAR ITCHING ASSOCIATED WITH SEASONAL ALLERGIC CONJUNCTIVITIS |
| Adult:
As trometamol: Instil 1 drop of a 0.5% solution into the affected eye/s 4 times daily. |
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| Ophthalmic |
| PREVENTION AND RELIEF OF POSTOPERATIVE EYE INFLAMMATION |
| Adult:
As trometamol: Instil 1 drop of a 0.5% solution into the appropriate eye/s 4 times daily starting 24 hr after surgery. Continue for 2 wk. |
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| Ophthalmic |
| PREVENTION AND RELIEF OF POSTOPERATIVE CYSTOID MACULAR OEDEMA ASSOCIATED WITH CATARACT EXTRACTION |
| Adult:
As trometamol: Instil 1-2 drops of a 0.5% solution into the appropriate eye/s every 6-8 hr starting 24 hr before surgery and continue for 3-4 wk after surgery. |
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| Ophthalmic |
| ACTIVE TREATMENT OF CHRONIC APHAKIC OR PSEUDOPHAKIC CYSTOID MACULAR OEDEMA |
| Adult:
s trometamol: Instil 1-2 drops of a 0.5% solution into the affected eye/s 4 times daily for 2-3 mth. |
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| Oral |
| REDUCTION OF OCULAR PAIN AND PHOTOPHOBIA IN PATIENTS UNDERGOING INCISIONAL REFRACTIVE SURGERY |
| Adult:
As trometamol: Instil 1 drop of a 0.5% solution 4 times daily into the operated eye for up to 3 days after surgery. |
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| Administration |
Should be taken with food. (Take immediately after meals.) |
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| Precautions |
Elderly, patients weighing <50 kg, hepatic dysfunction, heart failure, predisposition to reduced blood volume or renal blood flow. Mild renal impairment; monitor renal function closely. |
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Potentially Life-threatening
Adverse Drug Reactions |
GI ulcer, bleeding and perforation, drowsiness, rash, bronchospasm, hypotension, psychosis, dry mouth, fever, bradycardia, chest pain, dizziness, headache, sweating, oedema, pallor, liver function changes. Transient stinging and local irritation (ophthalmic). |
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| Adverse Drug Reactions |
Anaphylaxis. Severe skin reactions. MI, stroke, GI bleeding. |
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| Interactions |
May reduce effects of antihypertensives (e.g. ACE inhibitors or angiotensin II receptor antagonists). Increased risk of renal toxicity with ACE inhibitors, diuretics. Increased adverse effects with aspirin or other NSAIDs. Hallucinations may occur when used with fluoxetine, thiothixene, alprazolam |
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