Indication & Dosage |
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| Oral |
| TREATMENT OF CONSTIPATION |
| Adult:
Initially, 10-20 g (15-30 ml) daily as a single dose or in 2 divided doses; gradually adjust according to patient's response. Max dose: 45 ml/day. |
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| Oral |
| TREATMENT OF CONSTIPATION |
| Child:
As 3.35 mg/5 ml solution: 1 mth to 1 yr: 2.5 ml; 1-5 yr: 5 ml; 5-10 yr: 10 ml; 10-18 yr: 15 ml. All doses to be given bid. |
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| Oral |
| TREATMENT OF HEPATIC ENCEPHALOPATHY |
| Adult:
60-100 g (90-150 ml) daily in 3 divided doses; adjust to produce 2 or 3 soft stools each day. |
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| Rectal |
| TREATMENT OF HEPATIC ENCEPHALOPATHY |
| Adult:
Mix 200 g (300 ml) with 700 ml water or 0.9% sodium chloride as a retention enema. Retain enema for 30-60 minutes; repeat every 4-6 hr until oral medication can be administered |
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| Administration |
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.) |
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| Precautions |
Monitor electrolyte imbalance. Lactose intolerance; diabetics. |
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Potentially Life-threatening
Adverse Drug Reactions |
Diarrhoea (dose-related), nausea, vomiting, hypokalaemia, bloating and abdominal cramps. |
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| Adverse Drug Reactions |
Dehydration and hypernatraemia on aggressive treatment. |
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| Interactions |
May prevent release of mesalazine in the colon. Decreased effect with oral neomycin, antacids. |
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