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Indication & Dosage |
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| Oral |
| HYPERTENSION |
| Adult:
As hydrochloride: 10 mg once daily, increased after 2 wk to 20 mg daily if necessary. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach at least 15 mins before meals.) |
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| Precautions |
Left ventricular dysfunction, sick sinus syndrome (if pacemaker not fitted). |
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| Adverse Drug Reactions |
Tachycardia, oedema, flushing, headache, dizziness, asthenia, rash, diarrhoea, polyuria, palpitations, hypotension, drowsiness, myalgia. |
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| Interactions |
Plasma concentration reduced by inducers of CYP3A4 eg rifampicin, phenytoin, carbamazepine. Bioavailability also reduced by metoprolol and possibly propranolol. Plasma concentrations increased by inhibitors of CYP3A4 eg imidazole antifungals, erythromycin, ritonavir, fluoxetine. Alcohol may potentiate vasodilating effect. |
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