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Indication & Dosage |
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| Oral |
| ADJUNCTIVE THERAPY IN PARTIAL SEIZURES |
| Adult:
Initially 500 mg bid. May be increased by 500 mg bid at 2-4 wk intervals. |
| Max Dosage: 3 g/day. |
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| Oral |
| ADJUNCTIVE THERAPY IN PARTIAL SEIZURES |
| Child:
4-15 yr (<50 kg): Initially 10 mg/kg bid. May be increased by 10 mg/kg bid at 2-wk intervals. Adolescents ≥16 yr or 50 kg initially 500 mg bid. May be increased by 500 mg bid at 2-4 wk intervals. |
| Max Dosage: 60 mg/kg/day. |
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| Oral |
| MONOTHERAPY FOR PARTIAL SEIZURES WITH OR WITHOUT SECONDARY GENERALISATION |
| Adult:
Initially 250 mg bid increased after 2 wk to 500 mg bid. May be increased by 250 mg bid at 2 wk intervals. |
| Max Dosage: 3 g/day. |
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| Intravenous |
| ADJUNCTIVE THERAPY IN PARTIAL SEIZURES |
| Adult:
Initially 500mg bid via IV infusion over 15 min. May be increased by 500 mg bid at 2-4 wk intervals |
| Max Dosage: 3 g/day. |
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| Intravenous |
| ADJUNCTIVE THERAPY IN PARTIAL SEIZURES |
| Adult:
4-15 yr (<50 kg): Initially 10 mg/kg bid via IV infusion over 15 min. May be increased by 10 mg/kg bid at 2-wk intervals. Adolescents ≥16 yr or 50 kg initially 500mg bid via IV infusion over 15 min. May be increased by 500 mg bid at 2-4 wk intervals. |
| Max Dosage: 60 mg/kg/day. |
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| Intravenous |
| MONOTHERAPY FOR PARTIAL SEIZURES WITH OR WITHOUT SECONDARY GENERALISATION |
| Adult:
Initially 250 mg bid via IV infusion over 15 min. May be increased by 250 mg bid at 2 wk intervals. |
| Max Dosage: 3 g/day. |
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| Precautions |
Renal and hepatic impairment; pregnancy, lactation; patients undergoing haemodialysis. If psychotic symptoms (eg hallucination) and behavioural symptoms (eg agitation, anxiety) occur, reduce dosage. Abrupt withdrawal may result in increased seizure frequency. May impair ability to drive or operate machinery during initial therapy. |
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| Adverse Drug Reactions |
Somnolence, asthenia, dizziness, vertigo, depression, emotional instability, hostility, nervousness, ataxia, tremor, amnesia, headache, nausea, dyspepsia, diarrhoea, anorexia, rash, diplopia. |
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