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Indication & Dosage |
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| Ophthalmic |
| REDUCTION OF INTRAOCULAR PRESSURE IN OPEN-ANGLE GLAUCOMA AND OCULAR HYPERTENSION |
| Adult:
As hydrochloride: 0.5% solution: 1-2 drops of in the affected eye(s) once daily; may be given bid for more severe or uncontrolled glaucoma. 0.25% solution: 1-2 drops bid. |
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| Precautions |
Patients at risk of developing hypoglycaemia. DM. Thyrotoxicosis. Known diminished pulmonary function. Cerebrovascular insufficiency. Do not drive or operate machinery until vision is clear. Pregnancy and lactation. |
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| Adverse Drug Reactions |
Ocular stinging, burning, blepharoconjunctivitis, decreased heart rate, decreased BP, iridocyclitis, headache, transient ataxia, dizziness, lethargy, decreased corneal sensitivity, tearing, visual disturbances, urticaria and pruritus. |
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| Interactions |
Mydriasis may occur when used with epinephrine. Additive effects with catecholamine-depleting drugs e.g. reserpine. Possible AV conduction disturbances, LVF and hypotension with IV calcium antagonists. Additive prolongation of AV conduction time with digitalis and calcium antagonists. Additive hypotensive effects with phenothiazine-related agents. Additive effect with systemic β-blockers. |
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