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Indication & Dosage
 
 
Oral
ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
ACUTE BACTERIAL SINUSITIS
Adult: 500 mg once daily for 10-14 days. Alternatively, 750 mg once daily for 5 days.
 
Oral
COMMUNITY-ACQUIRED PNEUMONIA
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
NOSOCOMIAL PNEUMONIA
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
SKIN AND SKIN STRUCTURE INFECTIONS, COMPLICATED
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
UNCOMPLICATED UTI
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
COMPLICATED UTI
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
ACUTE PYELONEPHRITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
SKIN AND SKIN STRUCTURE INFECTIONS, UNCOMPLICATED
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
CHRONIC BACTERIAL PROSTATITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
TREATMENT AND POSTEXPOSURE PROPHYLAXIS OF INHALATION ANTHRAX
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
ACUTE BACTERIAL SINUSITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
COMMUNITY-ACQUIRED PNEUMONIA
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
NOSOCOMIAL PNEUMONIA
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
SKIN AND SKIN STRUCTURE INFECTIONS, COMPLICATED
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
UNCOMPLICATED UTI
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
COMPLICATED UTI
Adult: 250-500 mg once daily for 7-10 days.
 
Oral
ACUTE PYELONEPHRITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
SKIN AND SKIN STRUCTURE INFECTIONS, UNCOMPLICATED
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
CHRONIC BACTERIAL PROSTATITIS
Adult: 250-500 mg once daily for 7-10 days.
 
Intravenous
TREATMENT AND POSTEXPOSURE PROPHYLAXIS OF INHALATION ANTHRAX
Adult: 250-500 mg once daily for 7-10 days.
 
Ophthalmic
OCULAR INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS
Adult: 250-500 mg once daily for 7-10 days.
 
Ophthalmic
OCULAR INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS
Child: 250-500 mg once daily for 7-10 days.
   
Administration Oral soln: Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.)
Tab: May be taken with or without food. (Ensure adequate fluid intake.)
   
Precautions Known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis, epilepsy) or other risk factors that predispose to seizures. Avoid unnecessary exposure to sunlight or artificial UV light. History of prolonged QT interval, uncorrected electrolyte disturbances. DM (carefully monitor blood glucose levels). Periodically monitor renal, hepatic and haematopoietic functions during treatment. Pregnancy and lactation. Elderly. May impair ability to drive or operate machinery.
   
Potentially Life-threatening 
Adverse Drug Reactions		 Oral/IV: Nausea, diarrhoea, constipation, headache, insomnia, inj site reactions (IV). Ophthalmic: Transient decrease in vision, ocular burning, ocular pain or discomfort, foreign body sensation, headache, fever, pharyngitis, photophobia.
   
Adverse Drug Reactions Anaphylaxis.
   
Interactions Increased concentration of ciclosporin or tacrolimus. Reduced absorption with didanosine, ferrous sulfate or dietary supplements containing zinc, calcium, magnesium or iron. May increase plasma levels of theophylline. Increased risk of tendon rupture with corticosteroids. Reduced absorption with sucralfate and antacids containing magnesium and aluminium; administer at least 2 hr before or 2 hr after antacids. Increased half-life and decreased clearance of procainamide. Altered glucose levels with antidiabetic agents (e.g. insulin, glyburide).
   
   
 

 
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