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Indication & Dosage
 
 
Intravenous
TREATMENT OF VENTRICULAR ARRHYTHMIAS IN ADVANCED CARDIAC LIFE SUPPORT FOR CARDIAC ARREST DUE TO VENTRICULAR FIBRILLATION AND PULSELESS VENTRICULAR TACHYCARDIA
Adult: As hydrochloride: 1-1.5 mg/kg repeated as necessary to a total of 3 mg/kg.
 
Intravenous
INTRAVENOUS REGIONAL ANAESTHESIA
Adult: 50-300 mg (10-60 ml) of a 0.5% solution without adrenaline; max dose: 4 mg/kg.
 
Intramuscular
EMERGENCY TREATMENT OF VENTRICULAR ARRHYTHMIAS
Adult: As hydrochloride: 300 mg injected into the deltoid muscle, repeat after 60-90 min if necessary.
 
Parenteral
SYMPATHETIC NERVE BLOCK
Adult: As hydrochloride: 50 mg (5 ml) of a 1% solution for cervical block or 50-100 mg (5-10 ml) of a 1% solution for lumbar block.
 
Parenteral
INFILTRATION ANAESTHESIA
Adult: As hydrochloride: 5-300 mg (1-60 ml of a 0.5% solution or 0.5-30 ml of a 1% solution).
 
Parenteral
PERIPHERAL NERVE BLOCK
Adult: As hydrochloride: For brachial plexus block: 225-300 mg (15-20 ml) of a 1.5% solution; for intercostal nerve block: 30 mg (3 ml) of a 1% solution; for paracervical block: 100 mg (10 ml) of a 1% solution on each side, repeated not more frequently than every 90 minutes; for paravertebral block: 30-50 mg (3-5 ml) of a 1% solution; for pudendal block: 100 mg (10 ml) as a 1% solution on each side; for retrobulbar block: 120-200 mg (3-5 ml) of a 4% solution.
 
Rectal
SURFACE ANAESTHESIA
Adult: As hydrochloride 4 % with fluorescein: 1 or more drops as required.
 
Rectal
SURFACE ANAESTHESIA
Child: As hydrochloride 4 % with fluorescein : As directed by physician.
 
Rectal
HEMORRHOIDS
Adult: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day
 
Rectal
HEMORRHOIDS
Child: ≥12 yr: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.
 
Rectal
PERIANAL PAIN AND ITCHING
Adult: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.
 
Rectal
PERIANAL PAIN AND ITCHING
Child: ≥12 yr: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.
 
Ophthalmic
SURFACE ANAESTHESIA
Adult: As hydrochloride 4 % with fluorescein: 1 or more drops as required.
 
Ophthalmic
SURFACE ANAESTHESIA
Child: As hydrochloride 4 % with fluorescein : As directed by physician.
 
Topical/Cutaneous
SURFACE ANAESTHESIA
Adult: As eutectic mixture containing lidocaine base 2.5% and prilocaine base 2.5%: Apply cream to skin under an occlusive dressing before procedure. Use without an occlusive dressing for genital warts.
 
Mouth/Throat
SURFACE ANAESTHESIA
Adult: For pain: 300 mg (15 ml) of 2% solution rinsed and ejected for mouth and throat pain; or gargled and swallowed if necessary for pharyngeal pain. Not to be used more frequently than every 3 hr. Max (topical oral solution): 2.4 g/day. Before bronchoscopy, bronchography, laryngoscopy, oesophagoscopy, endotracheal intubation, and biopsy in the mouth and throat: 40-300 mg (1-7.5 ml) of 4% solution. For dentistry and otorhinolaryngology procedures: 10-50 mg of 10% solution sprayed to mucous membrane. For laryngotracheal anaesthesia: 160 mg of 4% solution sprayed or instilled as a single dose into the lumen of the larynx and trachea.
 
Urethral
SURFACE ANAESTHESIA
Adult: As 2% gel: Female: 60-100 mg inserted into the urethra several minutes before examination. Male: 100-200 mg before catheterisation and 600 mg before sounding or cystoscopy.
 
Epidural
EPIDURAL ANAESTHESIA
Adult: As hydrochloride: 2-3 ml solution administered for each dermatome to be anaesthesized. Recommended doses are: lumbar epidural 250-300 mg (25-30 ml of a 1% solution) for analgesia and 225-300 mg (15-20 ml of a 1.5% solution) or 200-300 mg (10-15 ml of a 2% solution) for anaesthesia; for thoracic epidural: 200-300 mg of a 1% solution. For obstetric caudal analgesia, up to 300 mg (30 ml of a 0.5% or 1% solution); for surgical caudal analgesia: 225-300 mg (15-20 ml of a 1.5% solution). For continuous epidural anaesthesia, not to repeat max doses more frequently than 1.5 hrly.
 
Intraspinal
SPINAL ANAESTHESIA
Adult: As hyperbaric solution of 1.5% or 5% lidocaine in 7.5% glucose solution. Normal vaginal delivery: 50 mg (1 ml) of a 5% solution or 9-15 mg (0.6-1 ml) of a 1.5% solution. Caesarian operation: Up to 75 mg (1.5 ml) of a 5% solution. Other surgical procedures: 75-100 mg (1.5-2 ml).
 
Injection
PUPIL DILATATION DURING PHACOEMULSIFICATION CATARACT SURGERY
Adult: As a 1% ophthalmic preservative-free solution (often used in combination with phenylephrine and cyclopentolate). To be injected into the anterior chamber of the eye at the beginning of the procedure.
   
Precautions Hepatic or renal impairment; CHF and following cardiac surgery; bradycardia; respiratory depression; porphyria; elderly or debilitated patients; pregnancy.
   
Potentially Life-threatening 
Adverse Drug Reactions
Dizziness, paraesthesia, drowsiness, confusion, respiratory depression and convulsions.
   
Adverse Drug Reactions Hypotension and bradycardia leading to cardiac arrest; anaphylaxis.
   
Interactions

Cimetidine and propranolol increase plasma concentration and toxicity. Increased risk of myocardial depression with beta blockers and other antiarrhythmics.

Additive cardiac effects with IV phenytoin. Effects antagonized by hypokalaemia caused by acetazolamide, loop diuretics and thiazides. Dose requirements may be increased with long-term use of phenytoin and other enzyme-inducers.

Decreased levels with St John's wort.

   
   
 

 

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