AS AN ADJUNCT IN THE MANAGEMENT OF ACUTE DIARRHOEA
Adult:
As hydrochloride: Initially, 4 mg followed by 2 mg after each loose stool. Usual dose: 6-8 mg daily. As oxide: Initially, 2-4 mg followed by 1 mg after each loose stool. Max dose as hydrochloride: 16 mg daily; as oxide: 8 mg daily
Oral
AS AN ADJUNCT IN THE MANAGEMENT OF ACUTE DIARRHOEA
Child:
As hydrochloride: 4-8 yr: 1 mg 3 or 4 times daily for up to 3 days; 9-12 yr: 2 mg 4 times daily for up to 5 days.
Oral
AS AN ADJUNCT IN THE MANAGEMENT OF CHRONIC DIARRHOEA
Adult:
As hydrochloride: Initially, 4-8 mg daily in divided doses, adjusted if necessary. Max: 16 mg daily; discontinue if no improvement at this dose after 10 days.
Oral
AS AN ADJUNCT IN THE MANAGEMENT OF CHRONIC DIARRHOEA
Child:
Treatment in children is generally not recommended but the following doses have been suggested: 1 mth-1 yr: As hydrochloride, 100-200 mcg/kg bid given 30 min before feeds (Max: 2 mg/kg daily); 1-12 yr: As hydrochloride, 100-200 mcg/kg (Max: 2 mg/dose) 3 to 4 times daily (Max: 16 mg daily).
Administration
May be taken with or without food.
Precautions
Concomitant specific therapy must be given in those with infectious diarrhoea; hepatic dysfunction; infants; pregnancy, lactation.
Potentially Life-threatening
Adverse Drug Reactions
Bioavailability increased by co-trimoxazole, ritonavir, saquinavir. Respiratory depression reported when administered with quinidine. Loperamide increases GI absorption of desmopressin and decreases exposure to saquinavir.
