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Indication & Dosage |
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| Oral |
| MANAGEMENT OF PSYCHOTIC DISORDERS |
Adult:
Adult: Initially, 20-50 mg daily in 2 divided doses. Increase according to patient response and tolerance over the next 7-10 days to 60-100 mg daily or more, in 2-4 divided doses. Max dose: 250 mg daily. Maintenance dose range: 20-100 mg daily in divided doses.
Elderly: 20-60 mg/day. |
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| Intravenous |
| CONTROL OF ACUTE PSYCHOTIC CONDITIONS |
| Adult:
Up to 300 mg daily in 2-3 divided doses.
Elderly: Reduced dose may be required. |
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| Administration |
Should be taken with food. |
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| Precautions |
Parkinson's disease. Haemodynamic instability; bone marrow suppression; predisposition to seizures; subcortical brain damage; severe cardiac, hepatic, renal or respiratory impairment. Patients at risk of pneumonia (e.g. Alzheimer's disease). Breast cancer or other prolactin-dependent tumours. Cerebrovascular disease. Decreased GI motility, urinary retention, benign prostatic hyperplasia, xerostomia or visual problems. Narrow-angle glaucoma; myasthenia gravis. May impair ability to drive or operate machinery. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Arrhythmia, BP changes, orthostatic hypotension, tachycardia, syncope; agitation, ataxia, confusion, dizziness, drowsiness, extrapyramidal symptoms, faintness, headache, insomnia, lightheadedness, seizure, slurred speech, tension; sexual dysfunction, urinary retention; agranulocytosis, leukopenia, thrombocytopenia; muscle weakness; alopecia, dermatitis, photosensitivity, pruritus, rash, seborrhoea; amenorrhoea, irregular menstruation, breast enlargement, galactorrhoea, gynaecomastia; ileus, constipation, nausea, vomiting, polydipsia, wt changes, xerostomia; blurred vision; nasal congestion. |
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| Adverse Drug Reactions |
Neuroleptic malignant syndrome. |
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| Interactions |
Additive CNS depression with other CNS depressants (e.g. benzodiazepines, barbiturates, alcohol). Inhibits vasopressor effect of epinephrine. CNS depression may be increased with kava kava, gotu kola, valerian, St John's wort. |
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