Indication & Dosage |
| |
| |
| Oral |
| PERIPHERAL NEUROPATHIES |
| Adult:
1500 mcg/day in 3 divided doses. |
| |
| Parenteral |
| PERIPHERAL NEUROPATHIES |
| Adult:
500 mcg daily IM/IV 3 times/wk. |
| |
| Parenteral |
| MEGALOBLASTIC ANAEMIA CAUSED BY VITAMIN B12 DEFICIENCY |
| Adult:
500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth. |
|
| |
|
| Administration |
May be taken with or without food. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site. |
| |
|
| Adverse Drug Reactions |
Anaphylactoid reactions (parenteral). |
| |
|
| Interactions |
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol. |
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