| |
| |
| Oral |
| AMOEBIASIS |
| Adult:
400-800 mg tid for 5-10 days or 1.5-2.5 g as a single daily dose for 2-3 days. Alternatively, 1.5-2.5 g as a single dose for 2-3 days. |
| |
| Oral |
| AMOEBIASIS |
| Child:
1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 35-50 mg/kg daily in divided doses. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| BALANTIDIASIS |
| Adult:
400-800 mg tid for 5-10 days or 1.5-2.5 g as a single daily dose for 2-3 days. Alternatively, 1.5-2.5 g as a single dose for 2-3 days. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| BALANTIDIASIS |
| Child:
1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 35-50 mg/kg daily in divided doses. |
| |
| Oral |
| BLASTOCYSTIS HOMINIS INFECTION |
| Adult:
400-800 mg tid for 5-10 days or 1.5-2.5 g as a single daily dose for 2-3 days. Alternatively, 1.5-2.5 g as a single dose for 2-3 days. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| BLASTOCYSTIS HOMINIS INFECTION |
| Child:
1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 35-50 mg/kg daily in divided doses. |
| |
| Oral |
| TRICHOMONIASIS |
| Adult:
2 g as a single dose, or 800 mg in the morning and 1.2 g in the evening for 2 days, or 0.6-1 g daily in 2-3 divided doses for 7 days. There should be an interval of 4-6 wk if treatment needs to be repeated. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| TRICHOMONIASIS |
| Child:
1-3 yr: 50 mg tid; 3-7 yr: 100 mg bid; 7-10 yr: 100 mg tid. All doses to be taken for 7 days. Alternatively, 15 mg/kg daily in divided doses for 7 days. |
| |
| Oral |
| GIARDIASIS |
| Adult:
2 g once daily for 3 consecutive days, or 400 mg tid for 5 days, or 500 mg bid for 7-10 days. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| GIARDIASIS |
| Child:
1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 15 mg/kg daily in divided doses. |
| |
| Oral |
| BACTERIAL VAGINOSIS |
| Adult:
2 g as a single dose, or 400-500 mg bid for 5-7 days. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| ACUTE NECROTISING ULCERATIVE GINGIVITIS |
| Adult:
200 mg tid for 3 days.
Elderly: Dose reductions may be required. |
| |
| Oral |
| ACUTE DENTAL INFECTIONS |
Adult:
200 mg tid for 3 days.
Elderly: Dose reductions may be required. |
| |
| Oral |
| ANAEROBIC INFECTIONS |
| Adult:
Initially, 800 mg followed by 400 mg 8 hly for about 7 days. Other recommended doses: 500 mg 8 hrly or 7.5 mg/kg 6 hrly (max: 4 g in 24 hr). Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Oral |
| ANAEROBIC INFECTIONS |
| Child:
7.5 mg/kg 8 hrly. |
| |
| Oral |
| PREVENTION OF POSTOPERATIVE ANAEROBIC BACTERIAL INFECTIONS |
Adult:
400 mg by mouth 8 hrly in the 24 hr prior to surgery followed postoperatively by IV or rectal admin until oral therapy is possible. Other sources recommend that oral doses be initiated only 2 hr prior to surgery and that number of doses for all admin routes be limited to a total of 4.
Elderly: Dose reduction may be necessary. |
| |
| Oral |
| ERADICATION OF H. PYLORI ASSOCIATED WITH PEPTIC ULCER DISEASE |
Adult:
In combination with another antibacterial (e.g. clarithromycin) plus either a proton pump inhibitor (e.g. lansoprazole) or ranitidine bismuth citrate: 400 mg bid. In combination with omeprazole and amoxicillin: 400 mg tid. Continue treatment for 1 wk.
Elderly: Dose reduction may be necessary. |
| |
| Oral |
| LEG ULCERS AND PRESSURE SORES INFECTED WITH ANAEROBIC BACTERIA |
Adult:
400 mg tid for 7 days.
Elderly: Dose reduction may be necessary. |
| |
| Oral |
| ANTIBIOTIC-ASSOCIATED COLITIS |
| Adult:
250-500 mg bid-tid for 10-14 days. Transfer to oral vancomycin is recommended if there is no clear clinical response after 2 days of treatment. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Intravenous |
| ANAEROBIC INFECTIONS |
| Adult:
500 mg infused as 100 ml of a 5 mg/ml solution at 5 ml/min 8 hrly. Alternatively, 15 mg/kg infusion followed by 7.5 mg/kg 6 hrly; infuse over 1 hr (max: 4 g in 24 hr). Substitute oral therapy as soon as possible. Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Intravenous |
| PREVENTION OF POSTOPERATIVE ANAEROBIC BACTERIAL INFECTIONS |
| Adult:
500 mg by IV infusion shortly before operation and repeated 8 hrly; oral doses of 200 or 400 mg 8 hrly being substituted as soon as possible. Patient undergoing colorectal surgery: 15 mg/kg infused over 30-60 min, completed about 1 hr prior to surgery, followed by 2 further IV doses of 7.5 mg/kg infused at 6 and 12 hr after the initial dose.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose. |
| |
| Rectal |
| ANAEROBIC INFECTIONS |
| Adult:
As a 1-g suppository 8 hrly for 3 days, then 12 hrly. Substitute oral therapy as soon as possible. May be unsuitable for initiating therapy in severe infections. Elderly: Dose reduction may be necessary. |
| |
| Rectal |
| ANAEROBIC INFECTIONS |
| Child:
<1 yr: 125 mg; 1-5 yr: 250 mg; 5-10 yr: 500 mg. All doses to be given 8 hrly for 3 days, then 12 hrly thereafter. May be unsuitable for initiating therapy in severe infections |
| |
| Rectal |
| PREVENTION OF POSTOPERATIVE ANAEROBIC BACTERIAL INFECTIONS |
Adult:
1 g 8 hrly starting 2 hr before surgery.
Elderly: Dose reduction may be necessary. |
| |
| Topical/Cutaneous |
| BACTERIAL VAGINOSIS |
| Child:
Apply 5 g of a 0.75% gel once or bid for 5 days. |
| |
| Topical/Cutaneous |
| ADJUNCT TO TREATMENT OF CHRONIC PERIODONTAL INFECTIONS |
| Adult:
Apply 25% dental gel to affected area. |
| |
| Topical/Cutaneous |
| REDUCTION OF ODOUR ASSOCIATED WITH ANAEROBIC INFECTION IN FUNGATING TUMOURS |
| Adult:
Apply as a 0.75 or 0.8% gel to the affected area. |
| |
| Topical/Cutaneous |
| ROSACEA |
| Adult:
Apply and rub a thin film once daily (1% formulation) or bid (0.75% formulation) to entire affected areas after washing. Significant response should be noticed within 3 wk. Clinical studies have demonstrated continuing improvement through 9 wk of therapy. |
