Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
| Adult:
Initially, 30-40 mg daily gradually increased if necessary. Maintenance: 30-90 mg daily as a single dose at night or in divided doses. Elderly: Initially, 30 mg slowly increased if necessary. |
| Max Dosage: 200 mg. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Concurrent CNS depression; epilepsy; MAOIs withdrawal (at least 14 days after discontinuation); hepatic, renal or cardiac insufficiency; heart block or recent MI; angle-closure glaucoma; prostatic hyperplasia; diabetes mellitus; monitor blood count regularly. |
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Potentially Life-threatening
Adverse Drug Reactions |
Drowsiness; liver dysfunction and jaundice; gynaecomastia; convulsions; hypomania; hypotension; hypertension; coma; arthralgia; oedema; tachycardia; bradycardia; vomiting; dizziness and ataxia; anticholinergic effects. |
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| Adverse Drug Reactions |
Bone marrow suppression. |
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| Interactions |
Avoid MAOIs (and for 14 days after discontinuation). Blood levels decreased by phenobarbitone, carbamazepine and phenytoin. Monitor blood pressure with antihypertensive therapy. Mianserin may antagonise the action of antiepileptics by lowering the convulsive threshold. CNS depressant effects enhance by alcohol, sedatives. |
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