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Indication & Dosage
 
 
Oral
TERMINATION OF PREGNANCY (49 DAYS OR LESS DURATION)
Adult:  600mg as a single dose followed 2 days later by 400 mcg of misoprostol as single dose.
 
Oral
POSTCOITAL CONTRACEPTION
Adult: 600 mg single dose within 72 hr of unprotected intercourse. 50 mg and 10 mg have also been used successfully.
 
Oral
TERMINATION OF PREGNANCY UP TO 63 DAYS
Adult: 600 mg as a single dose followed by 1 mg gemeprost vaginally after 36-48 hr.
 
Oral
INDUCTION OF LABOUR FOLLOWING INTRAUTERINE FETAL DEATH
Adult: 600 mg daily for 2 consecutive days.
 
Oral
TERMINATION OF PREGNANCY BETWEEN 13-24 WK OF GESTATION
Adult: 600 mg as a single dose given 36-48 hr prior to prostaglandin therapy.
 
Oral
SOFTENING AND DILATATION OF CERVIX PRIOR TO SURGICAL TERMINATION OF PREGNANCY
Adult: 600 mg as a single dose given 36-48 hr prior to the procedure.
   
Administration May be taken with or without food. (Avoid grapefruit juice.)
   
Precautions Asthma, COPD; women smokers >35 yr; CV disease or risk factors; smoking; alcoholism; prosthetic heart valve; history of infective endocarditis.
   
Adverse Drug Reactions Excessive vaginal bleeding; UTI; uterine haemorrhage; uterine infections; unusual tiredness or weakness; back pain; diarrhoea, nausea, vomiting; fever; dizziness; headache; anxiety; GI cramps.
   
Interactions Decreased efficacy with aspirin and NSAIDs. Efficacy of corticosteroids (including inhaled) decreased, monitor patients during co-admin and for several days afterwards.
   
   
 

 

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