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Indication & Dosage |
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| Oral |
| ACUTE HEART FAILURE |
| Adult:
Initially, a loading dose of 50 mcg/kg by slow IV injection over 10 min then continuous maintenance infusion of 0.375-0.75 mcg/kg/min. Adjust according to haemodynamics and clinical response. |
| Max Dosage: 1.13 mcg/kg/day. |
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| Oral |
| ACUTE HEART FAILURE |
| Child:
Initially, a loading dose of 50 mcg/kg by slow IV injection over 10 min then continuous maintenance infusion of 0.375-0.75 mcg/kg/min. Adjust according to haemodynamics and clinical response. Max dose 1.13 mcg/kg/day. |
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| Oral |
| SHORT-TERM MANAGEMENT OF SEVERE HEART FAILURE |
| Adult:
Initially, a loading dose of 50 mcg/kg by slow IV injection over 10 min then continuous maintenance infusion of 0.375-0.75 mcg/kg/min. Adjust according to haemodynamics and clinical response. Max dose 1.13 mcg/kg/day. |
| Max Dosage: 1.13 mcg/kg/day. |
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| Oral |
| SHORT-TERM MANAGEMENT OF SEVERE HEART FAILURE |
| Child:
Initial loading dose of 75 mcg/kg by IV injection over 10-60 min followed by continuous infusion of 0.5-0.75 mcg/kg/min. |
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| Precautions |
Severe obstructive aortic or pulmonary valvular disease, hypertrophic cardiomyopathy, atrial flutter or fibrillation. Monitor blood pressure, heart rate, ECG, fluid and electrolyte balance. Pregnancy and lactation. Use for >48 hr. |
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Potentially Life-threatening
Adverse Drug Reactions |
Angina-like chest pain, headache, hypokalaemia, tremor, thrombocytopenia, bronchospasm. |
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| Adverse Drug Reactions |
Supraventricular and ventricular arrhythmias; hypotension. |
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| Interactions |
Avoid anagrelide due the potential for increased inotropic effects. |
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