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Indication & Dosage |
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| Oral |
| TREATMENT OF BENIGN GASTRIC AND DUODENAL ULCERATION, NSAID-ASSOCIATED ULCERATION |
| Adult:
800 mcg daily in 2-4 divided doses for 4-8 wk. Elderly: Reduce dose if patients are unable to tolerate usual adult dose |
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| Oral |
| PREVENTION OF NSAID-INDUCED ULCERS |
| Adult:
200 mcg 2-4 times daily. Patient not tolerating high dose: Reduce dose to 100 mcg 4 times daily.
Elderly: Reduce dose if patients are unable to tolerate usual adult dose. |
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| Oral |
| CERVICAL RIPENING BEFORE SURGICAL TERMINATION OF PREGNANCY IN THE 1ST TRIMESTER |
| Adult:
400 mcg as a single dose 3-4 hr before surgery. |
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| Oral |
| TERMINATION OF PREGNANCY (49 DAYS OR LESS DURATION) |
| Adult:
400 mcg as a single dose 36-48 hr after mifepristone. |
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| Administration |
Should be taken with food. |
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| Precautions |
Conditions where hypotension might precipitate severe complications e.g. cerebrovascular or CV disease. Inflammatory bowel disease. Patients prone to dehydration. Elderly. Renal impairment. |
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| Adverse Drug Reactions |
Diarrhoea, abdominal pain, dyspepsia, constipation, flatulence, nausea and vomiting; abnormal vaginal bleeding, cramps, increased uterine contractility, headache. |
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| Interactions |
May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids. |
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