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Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
| Adult:
Initially, 300 mg daily in divided doses; increase up to 600 mg daily according to patient's response. Maintenance: 150 mg daily |
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| Oral |
| SOCIAL ANXIETY DISORDER |
| Adult:
Initially, 300 mg daily; increase to 600 mg in 2 divided doses after 3 days. Continue for 8-12 wk. |
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| Administration |
Should be taken with food. (Take immediately after meals.) |
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| Precautions |
Excited or agitated patients; bipolar disorders; hepatic impairment; thyrotoxicosis. Early antidepressant therapy; close monitoring particularly during periods of dosage adjustments. May impair ability to drive or operate machinery. Pregnancy and lactation. Withdrawal should be gradual. |
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Potentially Life-threatening
Adverse Drug Reactions |
Tachycardia, hypotension, dizziness, headache, drowsiness, sleep disturbances, agitation, nervousness, sedation, somnolence, anxiety, increased appetite, xerostomia, nausea, constipation, abdominal pain, diarrhoea, vomiting, weakness, blurred vision, increased sweating, increased transaminases, elevated creatine kinase (CK) and creatine phosphokinase (CPK). |
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| Adverse Drug Reactions |
Hypertensive crisis. |
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| Interactions |
Increased plasma concentrations with cimetidine. Behavioural and neurologic syndromes with tryptophan. Excessive sedation and acute hypotension with CNS depressants (opiates or others analgesics, barbiturates or other sedatives, anaesthetics or alcohol). Marked hypotensive effects with diuretics and hypotensive agents. Worsening of depression and/or suicidality with antidepressants. |
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