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Indication & Dosage |
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| Oral |
| OPIOID DEPENDENCE |
| Adult:
As hydrochloride: 200 mg to 3 g daily. |
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| Intravenous |
| REVERSAL OF CENTRAL DEPRESSION FROM OPIOID USE DURING SURGERY |
| Adult:
As hydrochloride: 100-200 mcg (1.5-3 mcg/kg) IV at 2 min intervals, titrate dose according to response while maintaining analgesia. |
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| Intravenous |
| REVERSAL OF CENTRAL DEPRESSION FROM OPIOID USE DURING SURGERY |
| Child:
As hydrochloride: 5-10 mcg IV at 2-3 min intervals. |
| |
| Parenteral |
| OPIOID OVERDOSAGE |
| Adult:
As hydrochloride: 200 mg to 3 g daily. |
| |
| Parenteral |
| OPIOID OVERDOSAGE |
| Child:
As hydrochloride: 200 mg to 3 g daily. |
| |
| Parenteral |
| OPIOID-INDUCED DEPRESSION IN NEONATES DUE TO OBSTETRIC ANALGESIA |
| Child:
As hydrochloride: 200 mg to 3 g daily. |
| |
| Parenteral |
| DIAGNOSIS OF OPIATE DEPENDENCE |
| Adult:
As hydrochloride: 200 mg to 3 g daily. |
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| Precautions |
Patients physically dependent on opioids, or who have received large doses of opioids (acute withdrawal syndrome may be precipitated). Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Occur secondarily to reversal (withdrawal) of narcotic analgesia and sedation. Mental depression, apathy, inability to concentrate, sleepiness, irritability, anorexia, nausea, and vomiting in high oral doses during initial treatment of opiate addiction. |
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| Adverse Drug Reactions |
Severe cardiopulmonary effects (e.g. hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnoea, pulmonary oedema, cardiac arrest) in postoperative patients, most frequently in those with preexisting CV disease. Recurrence of respiratory depression in long-acting opioids. |
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| Interactions |
Decreased effect of opioid analgesics. |
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