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Indication & Dosage |
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| Oral |
| HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS |
| Adult:
1.25 g bid or 0.75 g tid. |
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| Oral |
| HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS |
| Child:
2-13 yr: 45-55 mg/kg bid or 25-35 mg/kg tid. |
| Max Dosage: Child: 0.75 g tid. |
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| Administration |
Should be taken with food. |
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| Precautions |
Pregnancy. Hepatic and renal impairment; haemophilia A or B; diabetes. Monitor for signs of lipodystrophy. |
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| Adverse Drug Reactions |
Hyperglycaemia, dyslipidaemia and redistribution of body fat (protease paunch, buffalo hump, facial atrophy and heart engorgement); hypertriglyceridaemia, hypercholesterolaemia. Diarrhoea, rash, nausea, flatulence, decreased lymphocytes, decreased neutrophils, decreased haemoglobin, increased creatine kinase, increased transaminases. |
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| Interactions |
Reduced levels/effects with antacids, phenobarbital, carbamazepine, aminoglutethimide, phenytoin, rifampicin, nafcillin, nevirapine, omeprazole, nevirapine. Increased serum levels/effects with azole antifungal agents, cimetidine, efavirenz. Increased serum levels/effects of azithromycin, calcium channel blockers, clarithromycin, corticosteroids (e.g. fluticasone), mirtazapine, nateglinide, nefazodone, ciclosporin, sirolimus, tacrolimus, venlafaxine, eplerinone, fentanyl, atorvastatin, phosphodiesterase-5 (PDE-5) inhibitors, rifabutin, trazodone, TCAs. Reduced serum levels/effects of hormonal contraceptives, methadone, theophylline derivatives. |
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