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Indication & Dosage |
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| Oral |
| SHORT-TERM MANAGEMENT OF INSOMNIA |
Adult:
5 mg at night; increase to 10 mg if necessary.
Elderly: Max dose: 50% of normal adult dose. |
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| Oral |
| MANAGEMENT OF INFANTILE SPASMS |
| Child:
Infants: 125 mcg/kg bid; gradually increase to 250-500 mcg/kg bid. |
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| Administration |
May be taken with or without food. |
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| Precautions |
May induce anterograde amnesia; caution patients to have uninterrupted sleep of 7-8 hr after ingestion of dose. May impair ability to drive or operate machinery. Depression, especially if suicidal risk may be present. History of drug abuse or acute alcoholism. Hepatic and renal impairment. Respiratory disease. Debilitated patients. Patients who are at risk of falls. Children, elderly. Pregnancy and lactation. |
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| Adverse Drug Reactions |
Hypotension, palpitation; agitation, aggressiveness, amnesia, ataxia, confusion, delusions, disorientation, dizziness, fatigue, hallucination, hangover, headache, irritability, nightmares, psychoses, rage, restlessness, sedation; rash; changes in libido; constipation, diarrhoea, excessive salivation, heartburn, nausea, vomiting; granulocytopenia, leukopenia; falling, muscle weakness; blurred or double vision; tinnitus (associated with withdrawal); aspiration, increased bronchial secretion, dyspnoea. |
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| Interactions |
CNS depressant effect increased with alcohol, barbiturates, TCAs, phenothiazines, morphine derivatives. Effects may be antagonised by theophylline. Increased levels/effects with probenecid. Reduced levels/effects with rifampicin. May reduce effects of levodopa. Increased CNS depression may occur with valerian, kava kava, St John's wort, gotu kola. |
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