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Indication & Dosage |
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| Oral |
| ACUTE UNCOMPLICATED URINARY TRACT INFECTIONS |
| Adult:
50-100 mg 4 times daily for 7 days. Dual-release preparation: 100 mg bid. |
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| Oral |
| ACUTE UNCOMPLICATED URINARY TRACT INFECTIONS |
| Child:
>3 mth and older children: 3 mg/kg daily in 4 divided doses. |
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| Oral |
| PROPHYLAXIS OF UNCOMPLICATED UTI |
| Adult:
50-100 mg at bedtime. |
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| Oral |
| PROPHYLAXIS OF UNCOMPLICATED UTI |
| Child:
>3 mth and older children: 1 mg/kg once daily. |
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| Administration |
Should be taken with food. (Take w/ or immediately after meals.) |
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| Precautions |
Elderly. Monitor hepatic and pulmonary function during prolonged therapy. Pre-existing pulmonary, hepatic, neurological, or allergic disorders, predisposition to peripheral neuropathy e.g. renal impairment, anaemia, DM, electrolyte imbalance, debility, vitamin B deficiency. Withdraw if signs of peripheral neuropathy occur. Lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Nausea, vomiting, anorexia, abdominal pain, diarrhoea; headache, drowsiness, vertigo, dizziness, nystagmus, benign intracranial hypertension; rash, urticaria, pruritus, fever, sialadenitis, angioedema, erythema multiforme, exfoliative dermatitis, pancreatitis, lupus-like syndrome, myalgia, arthralgia; acute pulmonary sensitivity reactions; megaloblastic anaemia, leucopenia, granulocytopenia or agranulocytosis, thrombocytopenia, aplastic anaemia, haemolytic anaemia (in G6PD-deficient patients); transient alopecia; brownish discolouration of urine. |
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| Adverse Drug Reactions |
Peripheral polyneuropathy, hepatotoxicity, anaphylaxis, Stevens-Johnson syndrome, interstitial pneumonitis, pulmonary fibrosis. |
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| Interactions |
Reduced excretion with probenecid or sulfinpyrazone. Absorption reduced by magnesium trisilicate. Antagonistic effects with quinolone antibacterials. Reduced effects with carbonic anhydrase inhibitors or urinary alkalinisers. |
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