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Indication & Dosage |
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| Oral |
| MUSCLE SPASMS |
| Adult:
As citrate: 100 mg bid orally. |
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| Administration |
May be taken with or without food. (May be taken w/ meals if GI upset occurs.) |
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| Precautions |
Elderly; pregnancy and lactation. May impair ability to drive or operate machinery. CHF, cardiac decompensation, coronary insufficiency , tachycardia, or cardiac arrhythmias. History of drug abuse or acute alcoholism. |
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Potentially Life-threatening
Adverse Drug Reactions |
Palpitation, tachycardia; agitation, drowsiness, dizziness, euphoria, hallucination, headache, mental confusion; pruritus, urticaria; constipation, gastric irritation, nausea, vomiting, xerostomia; urination hesitancy, urinary retention; aplastic anaemia (rare); tremor, weakness; blurred vision, increased intraocular pressure, nystagmus, pupil dilatation; nasal congestion; hypersensitivity. |
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| Adverse Drug Reactions |
Anaphylactic reactions (rare). |
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| Interactions |
Reduced effect with acetylcholinesterase inhibitors e.g. donepezil, galantamine, rivastigmine, tacrine; may reduce effect of centrally-acting acetylcholinesterase inhibitors. Additive sedative effects with CNS depressants, alcohol. Pramlintide may increase anticholinergic effect on the GI tract. Increased risk of anticholinergic adverse effects with diphenhydramine, TCAs, phenothiazines. |
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