Indication & Dosage |
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| Oral |
| OBESITY |
| Adult:
120 mg tid with each main meal containing fat; omit dose if meal is occasionally missed or has no fat. |
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| Oral |
| OBESITY |
| Child:
≥12 yr: 120 mg tid with each main meal containing fat; omit dose if meal is occasionally missed or has no fat. |
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| Administration |
Should be taken with food. (Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.) |
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| Precautions |
Distribute daily intake of fat over 3 main meals. Fat-soluble vitamins supplements may be required during long-term therapy. Discontinue use if 5% body wt loss is not achieved during the first 12 wk. History of hyperoxaluria or calcium oxalate nephrolithiasis. DM. Pregnancy. |
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Potentially Life-threatening
Adverse Drug Reactions |
Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort. |
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| Adverse Drug Reactions |
Anaphylaxis; angioedema. |
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| Interactions |
May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin. |
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