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Indication & Dosage |
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| |
| Oral |
| RELIEF OF MUSCLE SPASMS |
| Adult:
As citrate: 100 mg bid orally. |
| |
| Oral |
| TREATMENT OF PARKINSONISM AND RELIEF FROM DRUG-INDUCED EXTRAPYRAMIDAL SYNDROME |
| Adult:
As hydrochloride: Initially, 150 mg daily in divided doses; increase gradually by 50 mg every 2-3 days depending on response. Maintenance: 150-300 mg/day. Some patients may require up to 400 mg daily. |
| Max Dosage: 400 mg/day. |
| |
| Parenteral |
| RELIEF OF MUSCLE SPASM |
| Adult:
As citrate: 60 mg every 12 hr by IM or slow IV (over 5 min) inj. |
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| Administration |
May be taken with or without food. (May be taken w/ meals if GI upset occurs.) |
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| Precautions |
Elderly; pregnancy and lactation. May impair ability to drive or operate machinery. CHF, cardiac decompensation, coronary insufficiency , tachycardia, or cardiac arrhythmias. History of drug abuse or acute alcoholism. |
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Potentially Life-threatening
Adverse Drug Reactions |
Palpitation, tachycardia; agitation, drowsiness, dizziness, euphoria, hallucination, headache, mental confusion; pruritus, urticaria; constipation, gastric irritation, nausea, vomiting, xerostomia; urination hesitancy, urinary retention; aplastic anaemia (rare); tremor, weakness; blurred vision, increased intraocular pressure, nystagmus, pupil dilatation; nasal congestion; hypersensitivity. |
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| Adverse Drug Reactions |
Anaphylactic reactions (rare). |
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