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Indication & Dosage |
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| Oral |
| ALCOHOL WITHDRAWAL SYNDROME |
| Adult:
15-30 mg 3 or 4 times daily.
Elderly: or debilitated patients: Initially, 10 mg tid; increase up to 10-20 mg 3 or 4 times daily as necessary. |
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| Oral |
| ANXIETY |
| Adult:
15-30 mg 3 or 4 times daily.
Elderly: or debilitated patients: Initially, 10 mg tid; increase up to 10-20 mg 3 or 4 times daily as necessary. |
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| Oral |
| INSOMNIA ASSOCIATED WITH ANXIETY |
| Adult:
15-25 mg given 1 hr before bedtime. Up to 50 mg may be occasionally required. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Cross-sensitivity with other benzodiazepines may occur. Hepatic and renal impairment. Respiratory disease. Debilitated patients, elderly, patients at risk of falls. Withdraw gradually. Porphyria; impaired gag reflex. History of drug abuse or acute alcoholism. May impair ability to drive or operate machinery. CV or cerebrovascular disease, intolerance to transient decreases in BP. Depression or if suicidal risk is present. |
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| Adverse Drug Reactions |
Syncope (rare), oedema; drowsiness, ataxia, dizziness, vertigo, memory impairment, headache, paradoxical reactions (excitement, stimulation of effect), lethargy, amnesia, euphoria; rash; decreased libido, menstrual irregularities; incontinence; leukopenia, blood dyscrasias; jaundice; dysarthria, tremor, reflex slowing; blurred vision, diplopia; drug dependence. |
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| Interactions |
Reduced sedative effects with theophylline and other CNS stimulants. Increased incidence of headache with zidovudine. May reduce effects of levodopa. |
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