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Indication & Dosage |
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| Oral |
| OVERACTIVE BLADDER |
| Adult:
2.5-5 mg bid-tid. May be increased to max 5 mg 4 times daily if necessary. As extended-release preparation: Initially, 5 mg once daily increased by 5 mg every wk if necessary to max 30 mg daily. |
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| Oral |
| OVERACTIVE BLADDER |
| Child:
>7 yr for nocturnal enuresis: 2.5-3 mg bid increased if necessary to 5 mg bid-tid. Last dose should be given before bedtime. As extended-release preparation: 5 mg once daily, increased by 5 mg wkly if necessary to max 20 mg daily. |
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| Oral |
| NEUROGENIC BLADDER DISORDERS |
| Child:
>5 yr: 2.5 or 3 mg bid increased to 5 mg bid according to response. Max 5 mg tid. |
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| Transdermal |
| OVERACTIVE BLADDER |
| Adult:
1 transdermal system (delivering 3.9 mg per day) applied to dry, intact skin on the abdomen, hip, or buttock twice wkly. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Elderly; hepatic or renal impairment; neuropathy; hyperthyroidism; prostatic hyperplasia; hiatus hernia; cardiac disease, reflux oesophagitis, ulcerative colitis, myasthenia gravis; pregnancy and lactation. High environmental temperature might cause heat prostration (fever with heat stroke due to decreased sweating). |
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| Adverse Drug Reactions |
Dry mouth, constipation, nausea, abdominal pain; blurred vision; headache, dizziness, drowsiness; dry skin, rash; photosensitivity, diarrhoea, insomnia, palpitation, weakness, dry eyes, confusion, hypertension, UTI, dyspepsia. |
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| Interactions |
Co-administration with other anticholinergic drugs may cause undesirable increased anticholinergic effects. Additive sedation with CNS depressants and alcohol. Concentration may be increased by CYP3A4 inhibitirs (e.g. imidazole antifungals, macrolide antibiotics). |
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