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Indication & Dosage |
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| Oral |
| TREATMENT OF PSYCHOSES |
| Adult:
Initially, 20-60 mg weekly, increased up to 250 mg once a wk in severe or resistant conditions. |
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| Precautions |
Pregnancy and lactation; elderly; epilepsy; preexisting cardiac conduction problems; hypokalaemia, hypomagnesemia; hypothyroidism. |
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Potentially Life-threatening
Adverse Drug Reactions |
Lower threshold for seizures, blurring of vision, dry mouth, retention of urine, constipation, orthostatic hypotension, weight gain, impaired glucose tolerance, allergic skin rashes, cholestatic jaundice; extrapyramidal effects; delirium; agitation, anxiety, depression, euphoria; anorexia, constipation, diarrhoea; alopecia; amenorrhoea, hypoglycaemia; hyponatraemia; hypersalivation, nausea, vomiting; bronchospasm; reported increased risk of breast cancer. |
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| Adverse Drug Reactions |
Blood dyscrasias; neuroleptic malignant syndrome; alteration of heart conduction leading to QT prolongation and life threatening arrhythmias. |
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| Interactions |
May produce neurotoxicity with lithium. Orthostatic hypotension with MAOIs; may increase sedation with alcohol, hypnotics, antihistamines, opiates; antacids containing aluminum salts may decrease absorption; additive antimuscarinic effects with TCAs; may reduce bromocriptine's ability to reduce serum prolactin; amphetamines may increase phycosis; may inihibit antiparkinsonian effects of levodopa; may increase risk of extrapyrimidal symptoms with metoclopramide; may increase phenytoin levels (phenytoin may reduce penfluridol levels); possible additive effects on QT interval with type 1a antiarrhythmics, TCAs, some quinolone antibiotics (eg moxifloxacin), may have additive hypotensive effects with trazodone; may increase levels of valproic acid. Avoid valerian, st john's wort, kava kava, gotta kola; increased risk of CNS depression. |
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