| |
| |
| Oral |
| WILSON'S DISEASE |
| Adult:
Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day. Initially, 1.5-2 g daily in divided doses. Maintenance dose: 0.75-1 g daily. |
| |
| Oral |
| WILSON'S DISEASE |
| Child:
1 mth-12 yr: 2.5 mg/kg bid, increased every 1-2 wk to 10 mg/kg bid. 12-18 yr: 0.75-1 g bid, max: 2 g daily for 1 yr; usual maintenance 0.75-1 g daily. Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day.
Elderly: Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day. Up to 20 mg/kg/day or 750 mg/day. |
| Max Dosage: 2 g daily for ≤ 1 yr. |
| |
| Oral |
| CYSTINURIA |
| Adult:
1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day. |
| |
| Oral |
| CYSTINURIA |
| Adult:
1 mth-12 yr: 5-10 mg/kg bid, 12-18 yr: 0.5-1.5 g bid. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day. |
| |
| Oral |
| LEAD POISONING |
| Adult:
1-2 g daily in 3 divided doses. Continue treatment until urinary lead is stabilised at <500 mcg/day. |
| |
| Oral |
| LEAD POISONING |
| Child:
20 mg/kg/day in 3 divided doses.
Elderly: 20 mg/kg/day in 3 divided doses. |
| |
| Oral |
| SEVERE ACTIVE RHEUMATOID ARTHRITIS |
| Adult:
As one part of a therapy programme. Initially 125-250 mg daily, increased gradually by the same amount at intervals of 4-12 wk up to 1-1.5 g/day. Discontinue if no response after 3-4 mth treatment with 1-1.5 g daily. Maintenance: 500-750 mg. Doses ≤500 mg/day: give as a single dose; doses > 500 mg: administer in divided doses. Max: 750 mg in older adults. |
| |
| Oral |
| SEVERE ACTIVE RHEUMATOID ARTHRITIS |
| Child:
As one part of a therapy programme. Initially, 3 mg/kg/day (≤250 mg/day for 3 mth, then 6 mg/kg/day (≤500 mg/day) bid for 3 mth. Max: 10 mg/kg/day in 3-4 divided doses (total max 750 mg/day).
Elderly: As one part of a therapy programme. Initially 50-125 mg daily; max: 750 mg/day. Doses ≤500 mg/day: give as a single dose; doses > 500 mg: administer in divided doses. |
| Max Dosage: Adult: 1.5 g/day. Elderly: 1 g/day. |
| |
| Oral |
| CHRONIC ACTIVE HEPATITIS |
| Adult:
Initially 500 mg daily in divided doses (after liver function tests shows disease controlled by corticosteroids). Dose gradually increased over 3 mth to 1250 mg daily with concurrent reduction in the corticosteroid dose.
Elderly: Not recommended. |
| |
| Oral |
| PREVENTION OF CYSTINE CALCULI |
| Adult:
0.5-1 g taken at bedtime. |
| |
| Oral |
| PREVENTION OF CYSTINE CALCULI |
| Child:
Use minimum dose required to maintain urinary cystine levels <200 mg/l.
Elderly: Use minimum dose required to maintain urinary cystine levels <200 mg/l. |
| |
| Oral |
| ARSENIC POISONING |
| Adult:
500 mg 4 times daily for 5 days. |
| |
| Oral |
| ARSENIC POISONING |
| Adult:
100 mg/kg/day in divided doses 6 hrly for 5 days; max: 1g/day. |
