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Indication & Dosage
 
 
Oral
TREATMENT OF PERIPHERAL VASCULAR DISORDERS
Adult: As modified-release formulation: 400 mg tid (normally for at least 8 weeks), reduce to 400 mg bid if adverse effects occur.
Adjust dose in patients with impaired renal function or severe hepatic impairment.
   
Administration Should be taken with food.
   
Precautions Ischaemic heart disease, hypotension. Adjust dosage in patients concomitantly on antihypertensives and hypoglycaemic agents. Impaired renal or liver function. Start at lower dose in elderly; safety and efficacy not established in children; tablets should not be chewed, crushed or broken.
   
Potentially Life-threatening 
Adverse Drug Reactions
Nausea, vomiting, dizziness, headache, flushing; angina, palpitations; occasional cardiac arrhythmias; hepatitis, jaundice; blood dyscrasias reported; agitation; sleep disturbances; hypotension; thrombocytopenia; intrahepatic cholestasis.
   
Adverse Drug Reactions Fatal haemorrhage (cerebral and GIT); anaphylactoid reaction.
   
Interactions

May potentiate antihypertensives. Increased bleeding with ketorolac and meloxicam.

High parenteral doses may enhance hypoglycaemic action of insulins in diabetic patients. Increase theophylline-serum levels.

Delays rate but not extent of absorption (serum levels may decrease if taken with food); administer with meals to minimise GI effects.

   
   
 

 

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