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Indication & Dosage |
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| Oral |
| VITAMIN K DEFICIENCY DUE TO DRUGS OR MALABSORPTION |
| Adult:
10-40 mg daily. |
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| Parenteral |
| TREATMENT OF VITAMIN K DEFICIENCY BLEEDING IN NEONATES |
| Child:
Infant: 1 mg by IV/IM/SC inj, further doses may be given if necessary |
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| Intramuscular |
| PREVENTION OF VIT K DEFICIENCY BLEEDING IN NEONATES |
| Child:
Neonate: 0.5-1 mg, given as a single dose via IM inj. Alternatively, 2 mg may be given orally, followed by a 2nd dose of 2 mg after 4-7 days. |
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| Intravenous |
| OVER-ANTICOAGULATION |
| Adult:
0.5-5 mg via slow IV inj. Dose depends on INR and degree of haemorrhage. |
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| Precautions |
Increased risk of severe haemolytic anaemia in neonates after large doses; severe hepatic impairment; pregnancy. Premature neonates weighing <2.5 kg. |
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| Adverse Drug Reactions |
Anaphylaxis, dyspnoea, cyanosis, pain, swelling, phloebitis at the Inj site, diaphoresis, dizziness, hypotension (rare), allergic reactions after SC and IM injection. |
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| Interactions |
Decreased effect of oral anticoagulants. |
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