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testing

 
   
PIPLIN  PIPRACIL  PIPRALIN  PIPREX  PRACIL 
 



Indication & Dosage
 
 
Oral
SERIOUS OR COMPLICATED INFECTIONS
Adult: As sodium: 200-300 mg/kg daily in divided doses or 3-4 g every 4 or 6 hr. For life-threatening conditions, daily dose of at least 16 mg is used.
Max Dosage:  24 g/day.
 
Oral
SERIOUS OR COMPLICATED INFECTIONS
Child: As sodium: 200-300 mg/kg daily in divided doses or 3-4 g every 4 or 6 hr. For life-threatening conditions, daily dose of at least 16 mg is used.
 
Intramuscular
UNCOMPLICATED GONORRHOEA
Adult: As sodium: 200-300 mg/kg daily in divided doses or 3-4 g every 4 or 6 hr. For life-threatening conditions, daily dose of at least 16 mg is used.
 
Parenteral
MILD OR UNCOMPLICATED INFECTIONS
Adult: As sodium: 200-300 mg/kg daily in divided doses or 3-4 g every 4 or 6 hr. For life-threatening conditions, daily dose of at least 16 mg is used.
 
Intramuscular
MILD OR UNCOMPLICATED INFECTIONS
Child: As sodium: 200-300 mg/kg daily in divided doses or 3-4 g every 4 or 6 hr. For life-threatening conditions, daily dose of at least 16 mg is used.
 
Parenteral
PROPHYLAXIS OF INFECTION DURING SURGERY
Adult: As sodium: 200-300 mg/kg daily in divided doses or 3-4 g every 4 or 6 hr. For life-threatening conditions, daily dose of at least 16 mg is used.
Max Dosage:  24 g/day.
   
Precautions Renal impairment; heart failure. Pregnancy. Prolonged treatment may increase risk of superinfection, leukopenia, neutropenia and bleeding manifestations. Increased risk of fever and rash in cystic fibrosis patients. Monitor renal, hepatic and haematological functions during prolonged and high-dose therapy.
   
Potentially Life-threatening 
Adverse Drug Reactions
GI disturbances; hypersensitivity reactions; eosinophilia, hyponatraemia, hypokalaemia. Injection-site related reactions such as pain, erythema and induration
   
Adverse Drug Reactions Anaphylactic reactions; prolongation of bleeding time; CNS toxicity
   
Interactions Clearance reduced by probenecid. May prolong bleeding time when used with anticoagulants. Increased risk of aminoglycoside-associated nephrotoxicity when used together. Concurrent use may increase risk of methotrexate toxicity due to reduced clearance. Increased neuromuscular block when used with neuromuscular blockers.
   
   
 

 

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