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Indication & Dosage |
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| Parenteral |
| ORGANOPHOSPHOROUS POISONING |
| Child:
As mesilate: 20-60 mg/kg. |
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| Parenteral |
| ORGANOPHOSPHOROUS POISONING |
| Adult:
Admin atropine via IM/IV inj until patient shows signs of atropine toxicity. Maintain atropinisation for at least 48 hr. As soon as the effects of atropine are observed, 1-2 g of pralidoxime (chloride, iodide or mesilate) may be given via IM/IV inj. Repeat dose after 1 hr, then every 8-12 hr, if necessary. In severe poisoning, continuous infusion of 200-500 mg/hr may be given, titrated against response. Max dose: 12 g/24 hr. |
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| Precautions |
Renal dysfunction, myasthenia gravis. Atropinisation may occur faster when atropine and pralidoxime are used together. Pregnancy, lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Drowsiness, dizziness, visual disturbances, nausea, tachycardia, headache, hyperventilation and muscle weakness. |
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| Adverse Drug Reactions |
Rapid admin causes tachycardia, laryngospasm and rigidity. Large doses cause neuromuscular blockade. |
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| Interactions |
Potentiates toxicity by carbamate pesticides. |
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