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Indication & Dosage |
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| Oral |
| MANAGEMENT OF HYPERTENSION |
| Adult:
As hydrochloride: Initially, 500 mcg bid-tid for 3-7 days, increased to 1 mg bid-tid for the next 3-7 days if tolerated, and gradually increased thereafter according to patient's response. Max dose: 20 mg daily. |
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| Oral |
| TREATMENT OF HEART FAILURE |
| Adult:
As hydrochloride: Initially, 500 mcg bid-qid, gradually increased according to response. Maintenance: 4-20 mg daily. |
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| Oral |
| BENIGN PROSTATIC HYPERPLASIA (BPH) |
| Adult:
Initially, 500 mcg bid, increased to a maintenance dose of ≤2 mg bid. |
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| Oral |
| RAYNAUD'S SYNDROME |
| Adult:
Initially, 500 mcg bid, increased to a maintenance dose of ≤2 mg bid |
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| Administration |
May be taken with or without food. (Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or without meals.) |
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| Precautions |
Angina pectoris. Ability to drive or operate machinery may be impaired. Phaeochromocytoma, abrupt withdrawal, impaired renal and liver function. child <12 yr. Lactation. May develop tolerance in prolonged treatment. Intiate treatment with low doses. |
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Potentially Life-threatening
Adverse Drug Reactions |
Postural hypotension, syncope, palpitations, lack of energy, nausea, oedema, chest pain, dyspnoea, constipation, diarrhoea, vomiting, depression, nervousness, sleep disturbances, headache, lassitude, drowsiness, loss of consciousness, dizziness, vertigo, hallucinations, paraesthesia, nasal congestion, epistaxis, dry mouth, urinary frequency and incontinence, pruritus, rash. |
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| Adverse Drug Reactions |
Rarely, hypotension may be life-threatening. |
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| Interactions |
May increase plasma concentrations of digoxin. Antihypertensive effect enhanced by other antihypertensive drugs. Diuretics and alcohol. Risk of 1st dose hypotension is increased in patients receiving b-blockers or calcium-channel blockers. |
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