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Indication & Dosage |
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| Oral |
| REATMENT OF PSYCHOSES |
| Adult:
As maleate or mesilate: 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily. |
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| Oral |
| TREATMENT OF PSYCHOSES |
| Child:
1-5 yr: 1.25-2.5 mg; 5-12 yr: 2.5-5 mg. May be given up to tid, if necessary. |
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| Intramuscular |
| MANAGEMENT OF SEVERE ANXIETY DISORDERS |
| Adult:
s maleate or mesilate: 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended dose: 3-6 mg bid. |
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| Oral |
| TREATMENT OF VERTIGO |
| Adult:
As maleate or mesilate: 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended dose: 3-6 mg bid. |
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| Intramuscular |
| TREATMENT OF NAUSEA AND VOMITING |
| Adult:
As mesilate: 12.5 mg by deep IM. If required, may give further doses via oral admin. |
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| Oral |
| TREATMENT OF PSYCHOSES |
| Adult:
As mesilate: 12.5-25 mg by deep IM Inj bid/tid. |
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| Rectal |
| TREATMENT OF NAUSEA AND VOMITING |
| Adult:
As maleate: 25 mg as suppository. If required, may give further doses via oral admin. |
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| Rectal |
| TREATMENT OF PSYCHOSES |
| Adult:
As maleate: 25 mg bid/tid. |
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| Buccal |
| TREATMENT OF NAUSEA AND VOMITING |
| Adult:
As maleate: 3-6 mg bid. |
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| Any Route |
| PREVENTION OF NAUSEA AND VOMITTING |
| Adult:
Oral/Rectal: As maleate or mesilate: 5-10 mg bid/tid. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Extrapyramidal syndrome, hypotension, epilepsy, impaired hepatic, renal, CV, cerebrovascular or respiratory function, glaucoma. May impair ability to drive or perform tasks requiring mental alertness or physical coordination. Parenteral use in children is not recommended. History of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations are recommended in patients on long-term treatment. |
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Potentially Life-threatening
Adverse Drug Reactions |
Cholestatic jaundice, cardiac arrhythmias, orthostatic hypotension, leucopaenia, thrombocytopaenia, dry mouth, blurring of vision, glaucoma, urinary retention, constipation, galactorrhoea, gynaecomastia, amenorrhoea and impotence. Buccal: Transient numbness of gum and tongue. |
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| Adverse Drug Reactions |
Bone-marrow suppression. Cardiac arrhythmias or aspiration. |
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| Interactions |
Additive anticholinergic effects with antihistamines, tricyclic antidepressants and drugs used in parkinsonism. May reduce the antihypertensive effect of guanethidine and other adrenergic neurone blockers. May also increase risk of arrhythmias when used with drugs that prolong QT interval. |
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