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Indication & Dosage |
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| Oral |
| SYMPTOMATIC TREATMENT OF PARKINSONISM AND DRUG-INDUCED EXTRAPYRAMIDAL SYNDROME |
Adult:
As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 days if required. Maintenance: 10-30 mg/day in 3 divided doses. Max dose: 60 mg daily.
Elderly: Lower doses are required. |
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| Oral |
| MANAGEMENT OF DYSTONIA IN CHILDREN |
| Child:
7-12 yr: 1.25 mg tid; 12-18 yr: 2.5 mg tid. For emergency cases, a single dose may be given via IM or IV inj: <2 yr: 0.5-2 mg; 2-10 yr: 2-5 mg and 10-18 yr: 5-10 mg. |
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| Oral |
| SYMPTOMATIC TREATMENT OF PARKINSONISM AND DRUG-INDUCED EXTRAPYRAMIDAL SYNDROME |
| Adult:
Emergency cases: 5-10 mg IV/IM. IM: May be repeated if necessary after 20 min up to 20 mg/day.
Elderly: Lower doses are required. |
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| Precautions |
Patients with diarrhoea. May impair a patient's ability to perform skilled tasks e.g. driving. May precipitate psychotic episodes in patients with mental disorders. Thyrotoxicosis, heart failure, acute myocardial infarction, hypertension. Childn, elderly. Pregnancy and lactation. Avoid abrupt withdrawal. |
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| Adverse Drug Reactions |
Excitability, dizziness, hallucinations (seen on abuse), dry mouth, blurred vision, constipation, urinary retention, agitation, restlessness, confusion and convulsions. |
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| Interactions |
Increased plasma concentrations when used with paroxetine. May counteract the GI effects of cisapride, domperidone and metoclopramide. May also reduce gastric motility, thus affecting the absorption of other drugs. |
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