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Indication & Dosage |
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| Oral |
| PROGESTOGEN COMPONENT OF MENOPAUSAL HRT |
| Adult:
200 mg daily as a single daily dose at night for 12-14 days of each mth. |
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| Oral |
| AMENORRHOEA |
| Adult:
400 mg daily for 10 days. |
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| Oral |
| DYSFUNCTIONAL UTERINE BLEEDING |
| Adult:
400 mg daily for 10 days. |
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| Intramuscular |
| DYSFUNCTIONAL UTERINE BLEEDING |
| Adult:
5-10 mg daily for 5-10 days until 2 days prior to expected onset of menstruation. |
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| Intramuscular |
| AMENORRHOEA |
| Adult:
5-10 mg daily for 5-10 days until 2 days prior to expected onset of menstruation. |
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| Intramuscular |
| RECURRENT MISCARRIAGE WITH PROGESTERONE DEFICIENCY |
| Adult:
25-100 mg twice wkly from the 15th day of pregnancy until 8-16 wk. May increase to daily inj, if necessary. |
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| Vaginal |
| DYSFUNCTIONAL UTERINE BLEEDING |
| Adult:
200 mg daily as a single daily dose at night for 12-14 days of each mth. |
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| Vaginal |
| AMENORRHOEA |
| Adult:
200 mg daily as a single daily dose at night for 12-14 days of each mth. |
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| Vaginal |
| PREMENSTRUAL SYNDROME |
| Adult:
200 mg daily as a single daily dose at night for 12-14 days of each mth. |
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| Intrauterine |
| CONTRACEPTION |
| Adult:
200 mg daily as a single daily dose at night for 12-14 days of each mth. |
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| Precautions |
Discontinue medications if there is sudden partial or complete loss of vision, proptosis or diplopia; migraine and embolic disorders; epilepsy, migraine, asthma, cardiac or renal dysfunction. History of depression, glucose tolerance and diabetic patients. May impair ability to drive or operate machinery. Avoid sudden withdrawal of progesterone; lactation. |
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| Adverse Drug Reactions |
GI disturbances, appetite/wt change, fluid retention, oedema, acne, skin rash, urticaria, depression, headache, fever, fatigue, breast changes, hirsutism, changes in libido, altered menstrual cycles or irregular menstrual bleeding (rare). |
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| Interactions |
Enhanced clearance with enzyme-inducing drugs eg, carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Ketoconazole may increase serum levels of progesterone. May inhibit ciclosporin metabolism. |
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