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Indication & Dosage |
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| Intravenous |
| INDUCTION OF GENERAL ANAESTHESIA |
| Adult:
40 mg by inj or infusion every 10 sec. Maintenance: 4-12 mg/kg/hr or intermittent bolus inj of 20-50 mg. Usual dose needed: 1.5-2.5 mg/kg. Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 sec. Maintenance: 3-6 mg/kg/hr. Usual dose needed: 1-1.5 mg/kg. |
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| Intravenous |
| INDUCTION OF GENERAL ANAESTHESIA |
| Child:
>8 yr: Induction dose of 2.5 mg/kg. Maintenance dose: 9-15 mg/kg/hr by IV infusion or intermittent bolus inj. |
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| Intravenous |
| SEDATION |
| Adult:
40 mg by inj or infusion every 10 sec. Maintenance: 4-12 mg/kg/hr or intermittent bolus inj of 20-50 mg. Usual dose needed: 1.5-2.5 mg/kg. Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 sec. Maintenance: 3-6 mg/kg/hr. Usual dose needed: 1-1.5 mg/kg. |
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| Precautions |
Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 yr. |
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Potentially Life-threatening
Adverse Drug Reactions |
Involuntary muscle movements; nausea, vomiting, headache, fever; pain, burning or stinging at inj site. |
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| Adverse Drug Reactions |
Apnoea, bradycardia, hypotension, convulsions; anaphylaxis. |
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| Interactions |
Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants. |
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